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Transcriptomic Analysis of CRISPR/Cas9-Mediated PARP1-Knockout Cells under the Influence of Topotecan and TDP1 Inhibitor

Topoisomerase 1 (TOP1) is an enzyme that regulates DNA topology and is essential for replication, recombination, and other processes. The normal TOP1 catalytic cycle involves the formation of a short-lived covalent complex with the 3′ end of DNA (TOP1 cleavage complex, TOP1cc), which can be stabiliz...

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Detalles Bibliográficos
Autores principales:	Dyrkheeva, Nadezhda S., Malakhova, Anastasia A., Zakharenko, Aleksandra L., Okorokova, Larisa S., Shtokalo, Dmitriy N., Pavlova, Sophia V., Medvedev, Sergey P., Zakian, Suren M., Nushtaeva, Anna A., Tupikin, Alexey E., Kabilov, Marsel R., Khodyreva, Svetlana N., Luzina, Olga A., Salakhutdinov, Nariman F., Lavrik, Olga I.
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	MDPI 2023
Materias:	Article
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10049738/ https://www.ncbi.nlm.nih.gov/pubmed/36982223 http://dx.doi.org/10.3390/ijms24065148

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