Cyclophosphamide-induced seizures in a patient with neuropsychiatric systemic lupus erythematosus (NPSLE): A case report

Seizures are life-threatening complications of neuropsychiatric systemic lupus erythematosus (NPSLE) and are often associated with poor outcomes. Cyclophosphamide immunotherapy is the mainstay of NPSLE treatment. We report the unique case of a patient with NPSLE who developed seizures soon after her...

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Autores principales: Zhang, Lingshu, Shi, Ying, Zhang, Jingyao, Wu, Jing, Jiang, Wei
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Frontiers Media S.A. 2023
Materias:
Immunology
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10049787/
https://www.ncbi.nlm.nih.gov/pubmed/36999036
http://dx.doi.org/10.3389/fimmu.2023.1122629
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author Zhang, Lingshu
Shi, Ying
Zhang, Jingyao
Wu, Jing
Jiang, Wei
author_facet Zhang, Lingshu
Shi, Ying
Zhang, Jingyao
Wu, Jing
Jiang, Wei
author_sort Zhang, Lingshu
collection PubMed
description Seizures are life-threatening complications of neuropsychiatric systemic lupus erythematosus (NPSLE) and are often associated with poor outcomes. Cyclophosphamide immunotherapy is the mainstay of NPSLE treatment. We report the unique case of a patient with NPSLE who developed seizures soon after her first and second doses of low-dose cyclophosphamide. The exact pathophysiological mechanism underlying cyclophosphamide-induced seizures is not well understood. However, this unusual drug-associated side effect of cyclophosphamide is thought to be due to the drug’s unique pharmacology. Clinicians should be aware of this complication to make a correct diagnosis and adjust the immunosuppressive regimens very carefully.
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spelling pubmed-100497872023-03-29 Cyclophosphamide-induced seizures in a patient with neuropsychiatric systemic lupus erythematosus (NPSLE): A case report Zhang, Lingshu Shi, Ying Zhang, Jingyao Wu, Jing Jiang, Wei Front Immunol Immunology Seizures are life-threatening complications of neuropsychiatric systemic lupus erythematosus (NPSLE) and are often associated with poor outcomes. Cyclophosphamide immunotherapy is the mainstay of NPSLE treatment. We report the unique case of a patient with NPSLE who developed seizures soon after her first and second doses of low-dose cyclophosphamide. The exact pathophysiological mechanism underlying cyclophosphamide-induced seizures is not well understood. However, this unusual drug-associated side effect of cyclophosphamide is thought to be due to the drug’s unique pharmacology. Clinicians should be aware of this complication to make a correct diagnosis and adjust the immunosuppressive regimens very carefully. Frontiers Media S.A. 2023-03-14 /pmc/articles/PMC10049787/ /pubmed/36999036 http://dx.doi.org/10.3389/fimmu.2023.1122629 Text en Copyright © 2023 Zhang, Shi, Zhang, Wu and Jiang https://creativecommons.org/licenses/by/4.0/This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) and the copyright owner(s) are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.
spellingShingle Immunology
Zhang, Lingshu
Shi, Ying
Zhang, Jingyao
Wu, Jing
Jiang, Wei
Cyclophosphamide-induced seizures in a patient with neuropsychiatric systemic lupus erythematosus (NPSLE): A case report
title Cyclophosphamide-induced seizures in a patient with neuropsychiatric systemic lupus erythematosus (NPSLE): A case report
title_full Cyclophosphamide-induced seizures in a patient with neuropsychiatric systemic lupus erythematosus (NPSLE): A case report
title_fullStr Cyclophosphamide-induced seizures in a patient with neuropsychiatric systemic lupus erythematosus (NPSLE): A case report
title_full_unstemmed Cyclophosphamide-induced seizures in a patient with neuropsychiatric systemic lupus erythematosus (NPSLE): A case report
title_short Cyclophosphamide-induced seizures in a patient with neuropsychiatric systemic lupus erythematosus (NPSLE): A case report
title_sort cyclophosphamide-induced seizures in a patient with neuropsychiatric systemic lupus erythematosus (npsle): a case report
topic Immunology
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10049787/
https://www.ncbi.nlm.nih.gov/pubmed/36999036
http://dx.doi.org/10.3389/fimmu.2023.1122629
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