Lonafarnib and everolimus reduce pathology in iPSC-derived tissue engineered blood vessel model of Hutchinson-Gilford Progeria Syndrome

Hutchinson-Gilford Progeria Syndrome (HGPS) is a rare, fatal genetic disease that accelerates atherosclerosis. With a limited pool of HGPS patients, clinical trials face unique challenges and require reliable preclinical testing. We previously reported a 3D tissue engineered blood vessel (TEBV) micr...

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Detalles Bibliográficos
Autores principales: Abutaleb, Nadia O., Atchison, Leigh, Choi, Leandro, Bedapudi, Akhil, Shores, Kevin, Gete, Yantenew, Cao, Kan, Truskey, George A.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Nature Publishing Group UK 2023
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10050176/
https://www.ncbi.nlm.nih.gov/pubmed/36977745
http://dx.doi.org/10.1038/s41598-023-32035-3

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