High-throughput screening of mutations affecting SARS-CoV-2 spike functions

The spike (S) protein of SARS-CoV-2, which is undergoing rapid evolution, plays crucial roles in viral immune escape, infectivity, and transmissibility. To gain clinical insight, Dadonaite et al. developed a novel deep mutational scanning (DMS) platform for mapping the effects of S protein mutations...

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Detalles Bibliográficos
Autores principales: Xia, Shuai, Liu, Zezhong, Jiang, Shibo
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Elsevier Ltd. 2023
Materias:
Spotlight
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10050277/
https://www.ncbi.nlm.nih.gov/pubmed/37031063
http://dx.doi.org/10.1016/j.it.2023.03.010
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author Xia, Shuai
Liu, Zezhong
Jiang, Shibo
author_facet Xia, Shuai
Liu, Zezhong
Jiang, Shibo
author_sort Xia, Shuai
collection PubMed
description The spike (S) protein of SARS-CoV-2, which is undergoing rapid evolution, plays crucial roles in viral immune escape, infectivity, and transmissibility. To gain clinical insight, Dadonaite et al. developed a novel deep mutational scanning (DMS) platform for mapping the effects of S protein mutations on immune evasion and viral infectivity.
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spelling pubmed-100502772023-03-29 High-throughput screening of mutations affecting SARS-CoV-2 spike functions Xia, Shuai Liu, Zezhong Jiang, Shibo Trends Immunol Spotlight The spike (S) protein of SARS-CoV-2, which is undergoing rapid evolution, plays crucial roles in viral immune escape, infectivity, and transmissibility. To gain clinical insight, Dadonaite et al. developed a novel deep mutational scanning (DMS) platform for mapping the effects of S protein mutations on immune evasion and viral infectivity. Elsevier Ltd. 2023-05 2023-03-29 /pmc/articles/PMC10050277/ /pubmed/37031063 http://dx.doi.org/10.1016/j.it.2023.03.010 Text en © 2023 Elsevier Ltd. All rights reserved. Since January 2020 Elsevier has created a COVID-19 resource centre with free information in English and Mandarin on the novel coronavirus COVID-19. The COVID-19 resource centre is hosted on Elsevier Connect, the company's public news and information website. Elsevier hereby grants permission to make all its COVID-19-related research that is available on the COVID-19 resource centre - including this research content - immediately available in PubMed Central and other publicly funded repositories, such as the WHO COVID database with rights for unrestricted research re-use and analyses in any form or by any means with acknowledgement of the original source. These permissions are granted for free by Elsevier for as long as the COVID-19 resource centre remains active.
spellingShingle Spotlight
Xia, Shuai
Liu, Zezhong
Jiang, Shibo
High-throughput screening of mutations affecting SARS-CoV-2 spike functions
title High-throughput screening of mutations affecting SARS-CoV-2 spike functions
title_full High-throughput screening of mutations affecting SARS-CoV-2 spike functions
title_fullStr High-throughput screening of mutations affecting SARS-CoV-2 spike functions
title_full_unstemmed High-throughput screening of mutations affecting SARS-CoV-2 spike functions
title_short High-throughput screening of mutations affecting SARS-CoV-2 spike functions
title_sort high-throughput screening of mutations affecting sars-cov-2 spike functions
topic Spotlight
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10050277/
https://www.ncbi.nlm.nih.gov/pubmed/37031063
http://dx.doi.org/10.1016/j.it.2023.03.010
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