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The influence of the BDNF Val66Met genotype on emotional recognition memory in post-traumatic stress disorder
Dysregulated consolidation of emotional memories is a core feature of posttraumatic stress disorder (PTSD). Brain Derived Neurotrophic Factor (BDNF) influences synaptic plasticity and emotional memory consolidation. The BDNF Val66Met polymorphism has been associated with PTSD risk and memory deficit...
Autores principales: | , , , , , |
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Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
Nature Publishing Group UK
2023
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Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10050310/ https://www.ncbi.nlm.nih.gov/pubmed/36977737 http://dx.doi.org/10.1038/s41598-023-30787-6 |
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author | Nicholson, Emma Louise Garry, Michael I. Ney, Luke J. Hsu, Chia-Ming K. Zuj, Daniel V. Felmingham, Kim L. |
author_facet | Nicholson, Emma Louise Garry, Michael I. Ney, Luke J. Hsu, Chia-Ming K. Zuj, Daniel V. Felmingham, Kim L. |
author_sort | Nicholson, Emma Louise |
collection | PubMed |
description | Dysregulated consolidation of emotional memories is a core feature of posttraumatic stress disorder (PTSD). Brain Derived Neurotrophic Factor (BDNF) influences synaptic plasticity and emotional memory consolidation. The BDNF Val66Met polymorphism has been associated with PTSD risk and memory deficits respectively, although findings have been inconsistent, potentially due to a failure to control for important confounds such as sex, ethnicity, and the timing/extent of previous trauma experiences. Furthermore, very little research has examined the impact of BDNF genotypes on emotional memory in PTSD populations. This study investigated the interaction effects of Val66Met and PTSD symptomatology in an emotional recognition memory task in 234 participants divided into healthy control (n = 85), trauma exposed (TE: n = 105) and PTSD (n = 44) groups. Key findings revealed impaired negative recognition memory in PTSD compared to control and TE groups and in participants with the Val/Met compared to the Val/Val genotype. There was a group × genotype interaction showing no Met effect in the TE group despite significant effects in PTSD and controls. Results suggest that people previously exposed to trauma who do not develop PTSD may be protected from the BDNF Met effect, however more research is needed to replicate findings and to explore the epigenetic and neural processes involved. |
format | Online Article Text |
id | pubmed-10050310 |
institution | National Center for Biotechnology Information |
language | English |
publishDate | 2023 |
publisher | Nature Publishing Group UK |
record_format | MEDLINE/PubMed |
spelling | pubmed-100503102023-03-30 The influence of the BDNF Val66Met genotype on emotional recognition memory in post-traumatic stress disorder Nicholson, Emma Louise Garry, Michael I. Ney, Luke J. Hsu, Chia-Ming K. Zuj, Daniel V. Felmingham, Kim L. Sci Rep Article Dysregulated consolidation of emotional memories is a core feature of posttraumatic stress disorder (PTSD). Brain Derived Neurotrophic Factor (BDNF) influences synaptic plasticity and emotional memory consolidation. The BDNF Val66Met polymorphism has been associated with PTSD risk and memory deficits respectively, although findings have been inconsistent, potentially due to a failure to control for important confounds such as sex, ethnicity, and the timing/extent of previous trauma experiences. Furthermore, very little research has examined the impact of BDNF genotypes on emotional memory in PTSD populations. This study investigated the interaction effects of Val66Met and PTSD symptomatology in an emotional recognition memory task in 234 participants divided into healthy control (n = 85), trauma exposed (TE: n = 105) and PTSD (n = 44) groups. Key findings revealed impaired negative recognition memory in PTSD compared to control and TE groups and in participants with the Val/Met compared to the Val/Val genotype. There was a group × genotype interaction showing no Met effect in the TE group despite significant effects in PTSD and controls. Results suggest that people previously exposed to trauma who do not develop PTSD may be protected from the BDNF Met effect, however more research is needed to replicate findings and to explore the epigenetic and neural processes involved. Nature Publishing Group UK 2023-03-28 /pmc/articles/PMC10050310/ /pubmed/36977737 http://dx.doi.org/10.1038/s41598-023-30787-6 Text en © The Author(s) 2023 https://creativecommons.org/licenses/by/4.0/Open Access This article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons licence, and indicate if changes were made. The images or other third party material in this article are included in the article's Creative Commons licence, unless indicated otherwise in a credit line to the material. If material is not included in the article's Creative Commons licence and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this licence, visit http://creativecommons.org/licenses/by/4.0/ (https://creativecommons.org/licenses/by/4.0/) . |
spellingShingle | Article Nicholson, Emma Louise Garry, Michael I. Ney, Luke J. Hsu, Chia-Ming K. Zuj, Daniel V. Felmingham, Kim L. The influence of the BDNF Val66Met genotype on emotional recognition memory in post-traumatic stress disorder |
title | The influence of the BDNF Val66Met genotype on emotional recognition memory in post-traumatic stress disorder |
title_full | The influence of the BDNF Val66Met genotype on emotional recognition memory in post-traumatic stress disorder |
title_fullStr | The influence of the BDNF Val66Met genotype on emotional recognition memory in post-traumatic stress disorder |
title_full_unstemmed | The influence of the BDNF Val66Met genotype on emotional recognition memory in post-traumatic stress disorder |
title_short | The influence of the BDNF Val66Met genotype on emotional recognition memory in post-traumatic stress disorder |
title_sort | influence of the bdnf val66met genotype on emotional recognition memory in post-traumatic stress disorder |
topic | Article |
url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10050310/ https://www.ncbi.nlm.nih.gov/pubmed/36977737 http://dx.doi.org/10.1038/s41598-023-30787-6 |
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