Roles of histone acetylation sites in cardiac hypertrophy and heart failure

Heart failure results from various physiological and pathological stimuli that lead to cardiac hypertrophy. This pathological process is common in several cardiovascular diseases and ultimately leads to heart failure. The development of cardiac hypertrophy and heart failure involves reprogramming of...

Descripción completa

Detalles Bibliográficos
Autores principales: Funamoto, Masafumi, Imanishi, Masaki, Tsuchiya, Koichiro, Ikeda, Yasumasa
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Frontiers Media S.A. 2023
Materias:
Cardiovascular Medicine
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10050342/
https://www.ncbi.nlm.nih.gov/pubmed/37008337
http://dx.doi.org/10.3389/fcvm.2023.1133611
_version_ 1785014628696195072
author Funamoto, Masafumi
Imanishi, Masaki
Tsuchiya, Koichiro
Ikeda, Yasumasa
author_facet Funamoto, Masafumi
Imanishi, Masaki
Tsuchiya, Koichiro
Ikeda, Yasumasa
author_sort Funamoto, Masafumi
collection PubMed
description Heart failure results from various physiological and pathological stimuli that lead to cardiac hypertrophy. This pathological process is common in several cardiovascular diseases and ultimately leads to heart failure. The development of cardiac hypertrophy and heart failure involves reprogramming of gene expression, a process that is highly dependent on epigenetic regulation. Histone acetylation is dynamically regulated by cardiac stress. Histone acetyltransferases play an important role in epigenetic remodeling in cardiac hypertrophy and heart failure. The regulation of histone acetyltransferases serves as a bridge between signal transduction and downstream gene reprogramming. Investigating the changes in histone acetyltransferases and histone modification sites in cardiac hypertrophy and heart failure will provide new therapeutic strategies to treat these diseases. This review summarizes the association of histone acetylation sites and histone acetylases with cardiac hypertrophy and heart failure, with emphasis on histone acetylation sites.
format Online
Article
Text
id pubmed-10050342
institution National Center for Biotechnology Information
language English
publishDate 2023
publisher Frontiers Media S.A.
record_format MEDLINE/PubMed
spelling pubmed-100503422023-03-30 Roles of histone acetylation sites in cardiac hypertrophy and heart failure Funamoto, Masafumi Imanishi, Masaki Tsuchiya, Koichiro Ikeda, Yasumasa Front Cardiovasc Med Cardiovascular Medicine Heart failure results from various physiological and pathological stimuli that lead to cardiac hypertrophy. This pathological process is common in several cardiovascular diseases and ultimately leads to heart failure. The development of cardiac hypertrophy and heart failure involves reprogramming of gene expression, a process that is highly dependent on epigenetic regulation. Histone acetylation is dynamically regulated by cardiac stress. Histone acetyltransferases play an important role in epigenetic remodeling in cardiac hypertrophy and heart failure. The regulation of histone acetyltransferases serves as a bridge between signal transduction and downstream gene reprogramming. Investigating the changes in histone acetyltransferases and histone modification sites in cardiac hypertrophy and heart failure will provide new therapeutic strategies to treat these diseases. This review summarizes the association of histone acetylation sites and histone acetylases with cardiac hypertrophy and heart failure, with emphasis on histone acetylation sites. Frontiers Media S.A. 2023-03-15 /pmc/articles/PMC10050342/ /pubmed/37008337 http://dx.doi.org/10.3389/fcvm.2023.1133611 Text en © 2023 Funamoto, Imanishi, Tsuchiya and Ikeda. https://creativecommons.org/licenses/by/4.0/This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY) (https://creativecommons.org/licenses/by/4.0/) . The use, distribution or reproduction in other forums is permitted, provided the original author(s) and the copyright owner(s) are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.
spellingShingle Cardiovascular Medicine
Funamoto, Masafumi
Imanishi, Masaki
Tsuchiya, Koichiro
Ikeda, Yasumasa
Roles of histone acetylation sites in cardiac hypertrophy and heart failure
title Roles of histone acetylation sites in cardiac hypertrophy and heart failure
title_full Roles of histone acetylation sites in cardiac hypertrophy and heart failure
title_fullStr Roles of histone acetylation sites in cardiac hypertrophy and heart failure
title_full_unstemmed Roles of histone acetylation sites in cardiac hypertrophy and heart failure
title_short Roles of histone acetylation sites in cardiac hypertrophy and heart failure
title_sort roles of histone acetylation sites in cardiac hypertrophy and heart failure
topic Cardiovascular Medicine
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10050342/
https://www.ncbi.nlm.nih.gov/pubmed/37008337
http://dx.doi.org/10.3389/fcvm.2023.1133611
work_keys_str_mv AT funamotomasafumi rolesofhistoneacetylationsitesincardiachypertrophyandheartfailure
AT imanishimasaki rolesofhistoneacetylationsitesincardiachypertrophyandheartfailure
AT tsuchiyakoichiro rolesofhistoneacetylationsitesincardiachypertrophyandheartfailure
AT ikedayasumasa rolesofhistoneacetylationsitesincardiachypertrophyandheartfailure

Ejemplares similares