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Natural products for kidney disease treatment: Focus on targeting mitochondrial dysfunction
The patients with kidney diseases are increasing rapidly all over the world. With the rich abundance of mitochondria, kidney is an organ with a high consumption of energy. Hence, renal failure is highly correlated with the breakup of mitochondrial homeostasis. However, the potential drugs targeting...
Autores principales: | , , |
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Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
Frontiers Media S.A.
2023
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Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10050361/ https://www.ncbi.nlm.nih.gov/pubmed/37007023 http://dx.doi.org/10.3389/fphar.2023.1142001 |
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author | Huang, Jiewu Liang, Ye Zhou, Lili |
author_facet | Huang, Jiewu Liang, Ye Zhou, Lili |
author_sort | Huang, Jiewu |
collection | PubMed |
description | The patients with kidney diseases are increasing rapidly all over the world. With the rich abundance of mitochondria, kidney is an organ with a high consumption of energy. Hence, renal failure is highly correlated with the breakup of mitochondrial homeostasis. However, the potential drugs targeting mitochondrial dysfunction are still in mystery. The natural products have the superiorities to explore the potential drugs regulating energy metabolism. However, their roles in targeting mitochondrial dysfunction in kidney diseases have not been extensively reviewed. Herein, we reviewed a series of natural products targeting mitochondrial oxidative stress, mitochondrial biogenesis, mitophagy, and mitochondrial dynamics. We found lots of them with great medicinal values in kidney disease. Our review provides a wide prospect for seeking the effective drugs targeting kidney diseases. |
format | Online Article Text |
id | pubmed-10050361 |
institution | National Center for Biotechnology Information |
language | English |
publishDate | 2023 |
publisher | Frontiers Media S.A. |
record_format | MEDLINE/PubMed |
spelling | pubmed-100503612023-03-30 Natural products for kidney disease treatment: Focus on targeting mitochondrial dysfunction Huang, Jiewu Liang, Ye Zhou, Lili Front Pharmacol Pharmacology The patients with kidney diseases are increasing rapidly all over the world. With the rich abundance of mitochondria, kidney is an organ with a high consumption of energy. Hence, renal failure is highly correlated with the breakup of mitochondrial homeostasis. However, the potential drugs targeting mitochondrial dysfunction are still in mystery. The natural products have the superiorities to explore the potential drugs regulating energy metabolism. However, their roles in targeting mitochondrial dysfunction in kidney diseases have not been extensively reviewed. Herein, we reviewed a series of natural products targeting mitochondrial oxidative stress, mitochondrial biogenesis, mitophagy, and mitochondrial dynamics. We found lots of them with great medicinal values in kidney disease. Our review provides a wide prospect for seeking the effective drugs targeting kidney diseases. Frontiers Media S.A. 2023-03-15 /pmc/articles/PMC10050361/ /pubmed/37007023 http://dx.doi.org/10.3389/fphar.2023.1142001 Text en Copyright © 2023 Huang, Liang and Zhou. https://creativecommons.org/licenses/by/4.0/This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) and the copyright owner(s) are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms. |
spellingShingle | Pharmacology Huang, Jiewu Liang, Ye Zhou, Lili Natural products for kidney disease treatment: Focus on targeting mitochondrial dysfunction |
title | Natural products for kidney disease treatment: Focus on targeting mitochondrial dysfunction |
title_full | Natural products for kidney disease treatment: Focus on targeting mitochondrial dysfunction |
title_fullStr | Natural products for kidney disease treatment: Focus on targeting mitochondrial dysfunction |
title_full_unstemmed | Natural products for kidney disease treatment: Focus on targeting mitochondrial dysfunction |
title_short | Natural products for kidney disease treatment: Focus on targeting mitochondrial dysfunction |
title_sort | natural products for kidney disease treatment: focus on targeting mitochondrial dysfunction |
topic | Pharmacology |
url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10050361/ https://www.ncbi.nlm.nih.gov/pubmed/37007023 http://dx.doi.org/10.3389/fphar.2023.1142001 |
work_keys_str_mv | AT huangjiewu naturalproductsforkidneydiseasetreatmentfocusontargetingmitochondrialdysfunction AT liangye naturalproductsforkidneydiseasetreatmentfocusontargetingmitochondrialdysfunction AT zhoulili naturalproductsforkidneydiseasetreatmentfocusontargetingmitochondrialdysfunction |