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Targeting Tn-positive tumors with an afucosylated recombinant anti-Tn IgG

The aberrant expression of the Tn antigen (CD175) on surface glycoproteins of human carcinomas is associated with tumorigenesis, metastasis, and poor survival. To target this antigen, we developed Remab6, a recombinant, human chimeric anti-Tn-specific monoclonal IgG. However, this antibody lacks ant...

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Detalles Bibliográficos
Autores principales:	Matsumoto, Yasuyuki, Jia, Nan, Heimburg-Molinaro, Jamie, Cummings, Richard D.
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	Nature Publishing Group UK 2023
Materias:	Article
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10050417/ https://www.ncbi.nlm.nih.gov/pubmed/36977722 http://dx.doi.org/10.1038/s41598-023-31195-6

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