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Role of MHC class I pathways in Mycobacterium tuberculosis antigen presentation

MHC class I antigen processing is an underappreciated area of nonviral host–pathogen interactions, bridging both immunology and cell biology, where the pathogen’s natural life cycle involves little presence in the cytoplasm. The effective response to MHC-I foreign antigen presentation is not only ce...

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Autor principal: Witt, Karolina D.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Frontiers Media S.A. 2023
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10050577/
https://www.ncbi.nlm.nih.gov/pubmed/37009503
http://dx.doi.org/10.3389/fcimb.2023.1107884
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author Witt, Karolina D.
author_facet Witt, Karolina D.
author_sort Witt, Karolina D.
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description MHC class I antigen processing is an underappreciated area of nonviral host–pathogen interactions, bridging both immunology and cell biology, where the pathogen’s natural life cycle involves little presence in the cytoplasm. The effective response to MHC-I foreign antigen presentation is not only cell death but also phenotypic changes in other cells and stimulation of the memory cells ready for the next antigen reoccurrence. This review looks at the MHC-I antigen processing pathway and potential alternative sources of the antigens, focusing on Mycobacterium tuberculosis (Mtb) as an intracellular pathogen that co-evolved with humans and developed an array of decoy strategies to survive in a hostile environment by manipulating host immunity to its own advantage. As that happens via the selective antigen presentation process, reinforcement of the effective antigen recognition on MHC-I molecules may stimulate subsets of effector cells that act earlier and more locally. Vaccines against tuberculosis (TB) could potentially eliminate this disease, yet their development has been slow, and success is limited in the context of this global disease’s spread. This review’s conclusions set out potential directions for MHC-I-focused approaches for the next generation of vaccines.
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spelling pubmed-100505772023-03-30 Role of MHC class I pathways in Mycobacterium tuberculosis antigen presentation Witt, Karolina D. Front Cell Infect Microbiol Cellular and Infection Microbiology MHC class I antigen processing is an underappreciated area of nonviral host–pathogen interactions, bridging both immunology and cell biology, where the pathogen’s natural life cycle involves little presence in the cytoplasm. The effective response to MHC-I foreign antigen presentation is not only cell death but also phenotypic changes in other cells and stimulation of the memory cells ready for the next antigen reoccurrence. This review looks at the MHC-I antigen processing pathway and potential alternative sources of the antigens, focusing on Mycobacterium tuberculosis (Mtb) as an intracellular pathogen that co-evolved with humans and developed an array of decoy strategies to survive in a hostile environment by manipulating host immunity to its own advantage. As that happens via the selective antigen presentation process, reinforcement of the effective antigen recognition on MHC-I molecules may stimulate subsets of effector cells that act earlier and more locally. Vaccines against tuberculosis (TB) could potentially eliminate this disease, yet their development has been slow, and success is limited in the context of this global disease’s spread. This review’s conclusions set out potential directions for MHC-I-focused approaches for the next generation of vaccines. Frontiers Media S.A. 2023-03-15 /pmc/articles/PMC10050577/ /pubmed/37009503 http://dx.doi.org/10.3389/fcimb.2023.1107884 Text en Copyright © 2023 Witt https://creativecommons.org/licenses/by/4.0/This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) and the copyright owner(s) are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.
spellingShingle Cellular and Infection Microbiology
Witt, Karolina D.
Role of MHC class I pathways in Mycobacterium tuberculosis antigen presentation
title Role of MHC class I pathways in Mycobacterium tuberculosis antigen presentation
title_full Role of MHC class I pathways in Mycobacterium tuberculosis antigen presentation
title_fullStr Role of MHC class I pathways in Mycobacterium tuberculosis antigen presentation
title_full_unstemmed Role of MHC class I pathways in Mycobacterium tuberculosis antigen presentation
title_short Role of MHC class I pathways in Mycobacterium tuberculosis antigen presentation
title_sort role of mhc class i pathways in mycobacterium tuberculosis antigen presentation
topic Cellular and Infection Microbiology
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10050577/
https://www.ncbi.nlm.nih.gov/pubmed/37009503
http://dx.doi.org/10.3389/fcimb.2023.1107884
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