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Temperature and sex shape Zika virus pathogenicity in the adult Brat(cheesehead) brain: A Drosophila model for virus-associated neurological diseases
Severe neurological complications affecting brain growth and function have been well documented in newborn and adult patients infected by Zika virus (ZIKV), but the underlying mechanisms remain unknown. Here we use a Drosophila melanogaster mutant, cheesehead (chs), with a mutation in the brain tumo...
Autores principales: | , , , , |
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Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
Elsevier
2023
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Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10050642/ https://www.ncbi.nlm.nih.gov/pubmed/37009222 http://dx.doi.org/10.1016/j.isci.2023.106424 |
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author | Tafesh-Edwards, Ghada Kalukin, Ananda Bunnell, Dean Chtarbanova, Stanislava Eleftherianos, Ioannis |
author_facet | Tafesh-Edwards, Ghada Kalukin, Ananda Bunnell, Dean Chtarbanova, Stanislava Eleftherianos, Ioannis |
author_sort | Tafesh-Edwards, Ghada |
collection | PubMed |
description | Severe neurological complications affecting brain growth and function have been well documented in newborn and adult patients infected by Zika virus (ZIKV), but the underlying mechanisms remain unknown. Here we use a Drosophila melanogaster mutant, cheesehead (chs), with a mutation in the brain tumor (brat) locus that exhibits both aberrant continued proliferation and progressive neurodegeneration in the adult brain. We report that temperature variability is a key driver of ZIKV pathogenesis, thereby altering host mortality and causing motor dysfunction in a sex-dependent manner. Furthermore, we show that ZIKV is largely localized to the brat(chs) brain and activates the RNAi and apoptotic immune responses. Our findings establish an in vivo model to study host innate immune responses and highlight the need of evaluating neurodegenerative deficits as a potential comorbidity in ZIKV-infected adults. |
format | Online Article Text |
id | pubmed-10050642 |
institution | National Center for Biotechnology Information |
language | English |
publishDate | 2023 |
publisher | Elsevier |
record_format | MEDLINE/PubMed |
spelling | pubmed-100506422023-03-30 Temperature and sex shape Zika virus pathogenicity in the adult Brat(cheesehead) brain: A Drosophila model for virus-associated neurological diseases Tafesh-Edwards, Ghada Kalukin, Ananda Bunnell, Dean Chtarbanova, Stanislava Eleftherianos, Ioannis iScience Article Severe neurological complications affecting brain growth and function have been well documented in newborn and adult patients infected by Zika virus (ZIKV), but the underlying mechanisms remain unknown. Here we use a Drosophila melanogaster mutant, cheesehead (chs), with a mutation in the brain tumor (brat) locus that exhibits both aberrant continued proliferation and progressive neurodegeneration in the adult brain. We report that temperature variability is a key driver of ZIKV pathogenesis, thereby altering host mortality and causing motor dysfunction in a sex-dependent manner. Furthermore, we show that ZIKV is largely localized to the brat(chs) brain and activates the RNAi and apoptotic immune responses. Our findings establish an in vivo model to study host innate immune responses and highlight the need of evaluating neurodegenerative deficits as a potential comorbidity in ZIKV-infected adults. Elsevier 2023-03-16 /pmc/articles/PMC10050642/ /pubmed/37009222 http://dx.doi.org/10.1016/j.isci.2023.106424 Text en © 2023 The Author(s) https://creativecommons.org/licenses/by-nc-nd/4.0/This is an open access article under the CC BY-NC-ND license (http://creativecommons.org/licenses/by-nc-nd/4.0/). |
spellingShingle | Article Tafesh-Edwards, Ghada Kalukin, Ananda Bunnell, Dean Chtarbanova, Stanislava Eleftherianos, Ioannis Temperature and sex shape Zika virus pathogenicity in the adult Brat(cheesehead) brain: A Drosophila model for virus-associated neurological diseases |
title | Temperature and sex shape Zika virus pathogenicity in the adult Brat(cheesehead) brain: A Drosophila model for virus-associated neurological diseases |
title_full | Temperature and sex shape Zika virus pathogenicity in the adult Brat(cheesehead) brain: A Drosophila model for virus-associated neurological diseases |
title_fullStr | Temperature and sex shape Zika virus pathogenicity in the adult Brat(cheesehead) brain: A Drosophila model for virus-associated neurological diseases |
title_full_unstemmed | Temperature and sex shape Zika virus pathogenicity in the adult Brat(cheesehead) brain: A Drosophila model for virus-associated neurological diseases |
title_short | Temperature and sex shape Zika virus pathogenicity in the adult Brat(cheesehead) brain: A Drosophila model for virus-associated neurological diseases |
title_sort | temperature and sex shape zika virus pathogenicity in the adult brat(cheesehead) brain: a drosophila model for virus-associated neurological diseases |
topic | Article |
url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10050642/ https://www.ncbi.nlm.nih.gov/pubmed/37009222 http://dx.doi.org/10.1016/j.isci.2023.106424 |
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