Copper overload impairs hematopoietic stem and progenitor cell proliferation via prompting HSF1/SP1 aggregation and the subsequently downregulating FOXM1-Cytoskeleton axis

Unbalanced Cu homeostasis has been suggested to be associated with hematopoietic disease, but the roles of Cu overload in the hematopoietic system and the potential mechanisms are obscure. Here, we report a novel association and the novel potential pathways for Cu overload to induce proliferation de...

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Detalles Bibliográficos
Autores principales: Li, LingYa, Tai, ZhiPeng, Liu, WenYe, Luo, Yi, Wu, You, Lin, ShuHui, Liu, Mugen, Gao, BaoXiang, Liu, Jing-Xia
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Elsevier 2023
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10050659/
https://www.ncbi.nlm.nih.gov/pubmed/37009226
http://dx.doi.org/10.1016/j.isci.2023.106406

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