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Overlapping cytokines in H. pylori infection and gastric cancer: A tandem meta-analysis

BACKGROUND: Previous evidence indicated that Helicobacter pylori-induced inflammation is the first step towards gastric carcinogenesis. However, investigations of the immunological factors driving this process have shown inconsistencies. We aimed to present a thorough summary of all researched cytok...

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Autores principales: Yu, Bingting, Xiang, Luochengling, Peppelenbosch, Maikel P., Fuhler, Gwenny M.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Frontiers Media S.A. 2023
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10050690/
https://www.ncbi.nlm.nih.gov/pubmed/37006300
http://dx.doi.org/10.3389/fimmu.2023.1125658
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author Yu, Bingting
Xiang, Luochengling
Peppelenbosch, Maikel P.
Fuhler, Gwenny M.
author_facet Yu, Bingting
Xiang, Luochengling
Peppelenbosch, Maikel P.
Fuhler, Gwenny M.
author_sort Yu, Bingting
collection PubMed
description BACKGROUND: Previous evidence indicated that Helicobacter pylori-induced inflammation is the first step towards gastric carcinogenesis. However, investigations of the immunological factors driving this process have shown inconsistencies. We aimed to present a thorough summary of all researched cytokines in relation to H. pylori infection and GC and relate these to global GC risk. METHODS: We performed a systematic review and tandem meta-analysis identifying all published studies reporting on serum cytokine levels in H. pylori-infected cases vs. non-infected controls and gastric cancer cases vs. non-gastric cancer controls, with sub-analyses performed to identify global regional differences in cytokine induction and their correlation with GC incidence. RESULTS: Only levels of systemic IL-6 (standardized mean difference [SMD]:0.95, 95%CI [0.45;1.45]) and TNF-α (SMD:0.88, 95%CI [0.46; 1.29]) were significantly increased upon H. pylori infection. Sub-analysis showed that of IL-6 levels were increased upon H. pylori infection in East Asian, Middle Eastern and Southeast Asian cohorts, but not in North America, Europe, Russia and Africa. Serum levels of IL-6, IL-7, IL-10, IL-12, and TNF-α were significantly raised in GC. Exploration of the relationship between serum cytokines changes upon H. pylori infection and regional differences in risk of GC development indicated that the SMD of IL-6 serum levels presents a significant correlation with the relative incidence of GC (r=0.81, p=0.00014). CONCLUSION: This study shows that H. pylori infection and GC are associated with increased IL-6 and TNF-α levels. Particularly, IL-6 shows region-specific increases that correlate with GC incidence, making it a key contender for the cause of this disease.
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spelling pubmed-100506902023-03-30 Overlapping cytokines in H. pylori infection and gastric cancer: A tandem meta-analysis Yu, Bingting Xiang, Luochengling Peppelenbosch, Maikel P. Fuhler, Gwenny M. Front Immunol Immunology BACKGROUND: Previous evidence indicated that Helicobacter pylori-induced inflammation is the first step towards gastric carcinogenesis. However, investigations of the immunological factors driving this process have shown inconsistencies. We aimed to present a thorough summary of all researched cytokines in relation to H. pylori infection and GC and relate these to global GC risk. METHODS: We performed a systematic review and tandem meta-analysis identifying all published studies reporting on serum cytokine levels in H. pylori-infected cases vs. non-infected controls and gastric cancer cases vs. non-gastric cancer controls, with sub-analyses performed to identify global regional differences in cytokine induction and their correlation with GC incidence. RESULTS: Only levels of systemic IL-6 (standardized mean difference [SMD]:0.95, 95%CI [0.45;1.45]) and TNF-α (SMD:0.88, 95%CI [0.46; 1.29]) were significantly increased upon H. pylori infection. Sub-analysis showed that of IL-6 levels were increased upon H. pylori infection in East Asian, Middle Eastern and Southeast Asian cohorts, but not in North America, Europe, Russia and Africa. Serum levels of IL-6, IL-7, IL-10, IL-12, and TNF-α were significantly raised in GC. Exploration of the relationship between serum cytokines changes upon H. pylori infection and regional differences in risk of GC development indicated that the SMD of IL-6 serum levels presents a significant correlation with the relative incidence of GC (r=0.81, p=0.00014). CONCLUSION: This study shows that H. pylori infection and GC are associated with increased IL-6 and TNF-α levels. Particularly, IL-6 shows region-specific increases that correlate with GC incidence, making it a key contender for the cause of this disease. Frontiers Media S.A. 2023-03-15 /pmc/articles/PMC10050690/ /pubmed/37006300 http://dx.doi.org/10.3389/fimmu.2023.1125658 Text en Copyright © 2023 Yu, Xiang, Peppelenbosch and Fuhler https://creativecommons.org/licenses/by/4.0/This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) and the copyright owner(s) are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.
spellingShingle Immunology
Yu, Bingting
Xiang, Luochengling
Peppelenbosch, Maikel P.
Fuhler, Gwenny M.
Overlapping cytokines in H. pylori infection and gastric cancer: A tandem meta-analysis
title Overlapping cytokines in H. pylori infection and gastric cancer: A tandem meta-analysis
title_full Overlapping cytokines in H. pylori infection and gastric cancer: A tandem meta-analysis
title_fullStr Overlapping cytokines in H. pylori infection and gastric cancer: A tandem meta-analysis
title_full_unstemmed Overlapping cytokines in H. pylori infection and gastric cancer: A tandem meta-analysis
title_short Overlapping cytokines in H. pylori infection and gastric cancer: A tandem meta-analysis
title_sort overlapping cytokines in h. pylori infection and gastric cancer: a tandem meta-analysis
topic Immunology
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10050690/
https://www.ncbi.nlm.nih.gov/pubmed/37006300
http://dx.doi.org/10.3389/fimmu.2023.1125658
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