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The role of NOD-like receptors in innate immunity
The innate immune system in vertebrates and invertebrates relies on conserved receptors and ligands, and pathways that can rapidly initiate the host response against microbial infection and other sources of stress and danger. Research into the family of NOD-like receptors (NLRs) has blossomed over t...
Autores principales: | , , , |
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Formato: | Online Artículo Texto |
Lenguaje: | English |
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Frontiers Media S.A.
2023
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Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10050748/ https://www.ncbi.nlm.nih.gov/pubmed/37006312 http://dx.doi.org/10.3389/fimmu.2023.1122586 |
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author | Almeida-da-Silva, Cássio Luiz Coutinho Savio, Luiz Eduardo Baggio Coutinho-Silva, Robson Ojcius, David M. |
author_facet | Almeida-da-Silva, Cássio Luiz Coutinho Savio, Luiz Eduardo Baggio Coutinho-Silva, Robson Ojcius, David M. |
author_sort | Almeida-da-Silva, Cássio Luiz Coutinho |
collection | PubMed |
description | The innate immune system in vertebrates and invertebrates relies on conserved receptors and ligands, and pathways that can rapidly initiate the host response against microbial infection and other sources of stress and danger. Research into the family of NOD-like receptors (NLRs) has blossomed over the past two decades, with much being learned about the ligands and conditions that stimulate the NLRs and the outcomes of NLR activation in cells and animals. The NLRs play key roles in diverse functions, ranging from transcription of MHC molecules to initiation of inflammation. Some NLRs are activated directly by their ligands, while other ligands may have indirect effects on the NLRs. New findings in coming years will undoubtedly shed more light on molecular details involved in NLR activation, as well as the physiological and immunological outcomes of NLR ligation. |
format | Online Article Text |
id | pubmed-10050748 |
institution | National Center for Biotechnology Information |
language | English |
publishDate | 2023 |
publisher | Frontiers Media S.A. |
record_format | MEDLINE/PubMed |
spelling | pubmed-100507482023-03-30 The role of NOD-like receptors in innate immunity Almeida-da-Silva, Cássio Luiz Coutinho Savio, Luiz Eduardo Baggio Coutinho-Silva, Robson Ojcius, David M. Front Immunol Immunology The innate immune system in vertebrates and invertebrates relies on conserved receptors and ligands, and pathways that can rapidly initiate the host response against microbial infection and other sources of stress and danger. Research into the family of NOD-like receptors (NLRs) has blossomed over the past two decades, with much being learned about the ligands and conditions that stimulate the NLRs and the outcomes of NLR activation in cells and animals. The NLRs play key roles in diverse functions, ranging from transcription of MHC molecules to initiation of inflammation. Some NLRs are activated directly by their ligands, while other ligands may have indirect effects on the NLRs. New findings in coming years will undoubtedly shed more light on molecular details involved in NLR activation, as well as the physiological and immunological outcomes of NLR ligation. Frontiers Media S.A. 2023-03-15 /pmc/articles/PMC10050748/ /pubmed/37006312 http://dx.doi.org/10.3389/fimmu.2023.1122586 Text en Copyright © 2023 Almeida-da-Silva, Savio, Coutinho-Silva and Ojcius https://creativecommons.org/licenses/by/4.0/This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) and the copyright owner(s) are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms. |
spellingShingle | Immunology Almeida-da-Silva, Cássio Luiz Coutinho Savio, Luiz Eduardo Baggio Coutinho-Silva, Robson Ojcius, David M. The role of NOD-like receptors in innate immunity |
title | The role of NOD-like receptors in innate immunity |
title_full | The role of NOD-like receptors in innate immunity |
title_fullStr | The role of NOD-like receptors in innate immunity |
title_full_unstemmed | The role of NOD-like receptors in innate immunity |
title_short | The role of NOD-like receptors in innate immunity |
title_sort | role of nod-like receptors in innate immunity |
topic | Immunology |
url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10050748/ https://www.ncbi.nlm.nih.gov/pubmed/37006312 http://dx.doi.org/10.3389/fimmu.2023.1122586 |
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