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Monitoring the Release of Methylglyoxal (MGO) from Honey and Honey-Based Formulations
Methylglyoxal (MGO) is considered to be one of the vital components responsible for the anti-bacterial activity of Leptospermum spp. (Manuka) honey. While many studies have demonstrated a dose-dependent antibacterial activity for MGO in vitro, from a therapeutic viewpoint, it is also important to co...
Autores principales: | , , , , |
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Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
MDPI
2023
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Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10051060/ https://www.ncbi.nlm.nih.gov/pubmed/36985830 http://dx.doi.org/10.3390/molecules28062858 |
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author | Hossain, Md Lokman Lim, Lee Yong Hammer, Katherine Hettiarachchi, Dhanushka Locher, Cornelia |
author_facet | Hossain, Md Lokman Lim, Lee Yong Hammer, Katherine Hettiarachchi, Dhanushka Locher, Cornelia |
author_sort | Hossain, Md Lokman |
collection | PubMed |
description | Methylglyoxal (MGO) is considered to be one of the vital components responsible for the anti-bacterial activity of Leptospermum spp. (Manuka) honey. While many studies have demonstrated a dose-dependent antibacterial activity for MGO in vitro, from a therapeutic viewpoint, it is also important to confirm its release from Manuka honey and also from Manuka honey-based formulations. This study is the first to report on the release profile of MGO from five commercial products containing Manuka honey using a Franz diffusion cell and High-Performance Liquid Chromatography (HPLC) analysis. The release of MGO expressed as percentage release of MGO content at baseline was monitored over a 12 h period and found to be 99.49 and 98.05% from an artificial honey matrix and NZ Manuka honey, respectively. For the investigated formulations, a time-dependent % MGO release between 85% and 97.18% was noted over the 12 h study period. |
format | Online Article Text |
id | pubmed-10051060 |
institution | National Center for Biotechnology Information |
language | English |
publishDate | 2023 |
publisher | MDPI |
record_format | MEDLINE/PubMed |
spelling | pubmed-100510602023-03-30 Monitoring the Release of Methylglyoxal (MGO) from Honey and Honey-Based Formulations Hossain, Md Lokman Lim, Lee Yong Hammer, Katherine Hettiarachchi, Dhanushka Locher, Cornelia Molecules Article Methylglyoxal (MGO) is considered to be one of the vital components responsible for the anti-bacterial activity of Leptospermum spp. (Manuka) honey. While many studies have demonstrated a dose-dependent antibacterial activity for MGO in vitro, from a therapeutic viewpoint, it is also important to confirm its release from Manuka honey and also from Manuka honey-based formulations. This study is the first to report on the release profile of MGO from five commercial products containing Manuka honey using a Franz diffusion cell and High-Performance Liquid Chromatography (HPLC) analysis. The release of MGO expressed as percentage release of MGO content at baseline was monitored over a 12 h period and found to be 99.49 and 98.05% from an artificial honey matrix and NZ Manuka honey, respectively. For the investigated formulations, a time-dependent % MGO release between 85% and 97.18% was noted over the 12 h study period. MDPI 2023-03-22 /pmc/articles/PMC10051060/ /pubmed/36985830 http://dx.doi.org/10.3390/molecules28062858 Text en © 2023 by the authors. https://creativecommons.org/licenses/by/4.0/Licensee MDPI, Basel, Switzerland. This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution (CC BY) license (https://creativecommons.org/licenses/by/4.0/). |
spellingShingle | Article Hossain, Md Lokman Lim, Lee Yong Hammer, Katherine Hettiarachchi, Dhanushka Locher, Cornelia Monitoring the Release of Methylglyoxal (MGO) from Honey and Honey-Based Formulations |
title | Monitoring the Release of Methylglyoxal (MGO) from Honey and Honey-Based Formulations |
title_full | Monitoring the Release of Methylglyoxal (MGO) from Honey and Honey-Based Formulations |
title_fullStr | Monitoring the Release of Methylglyoxal (MGO) from Honey and Honey-Based Formulations |
title_full_unstemmed | Monitoring the Release of Methylglyoxal (MGO) from Honey and Honey-Based Formulations |
title_short | Monitoring the Release of Methylglyoxal (MGO) from Honey and Honey-Based Formulations |
title_sort | monitoring the release of methylglyoxal (mgo) from honey and honey-based formulations |
topic | Article |
url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10051060/ https://www.ncbi.nlm.nih.gov/pubmed/36985830 http://dx.doi.org/10.3390/molecules28062858 |
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