Cargando…

Monitoring the Release of Methylglyoxal (MGO) from Honey and Honey-Based Formulations

Methylglyoxal (MGO) is considered to be one of the vital components responsible for the anti-bacterial activity of Leptospermum spp. (Manuka) honey. While many studies have demonstrated a dose-dependent antibacterial activity for MGO in vitro, from a therapeutic viewpoint, it is also important to co...

Descripción completa

Detalles Bibliográficos
Autores principales: Hossain, Md Lokman, Lim, Lee Yong, Hammer, Katherine, Hettiarachchi, Dhanushka, Locher, Cornelia
Formato: Online Artículo Texto
Lenguaje:English
Publicado: MDPI 2023
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10051060/
https://www.ncbi.nlm.nih.gov/pubmed/36985830
http://dx.doi.org/10.3390/molecules28062858
_version_ 1785014783282511872
author Hossain, Md Lokman
Lim, Lee Yong
Hammer, Katherine
Hettiarachchi, Dhanushka
Locher, Cornelia
author_facet Hossain, Md Lokman
Lim, Lee Yong
Hammer, Katherine
Hettiarachchi, Dhanushka
Locher, Cornelia
author_sort Hossain, Md Lokman
collection PubMed
description Methylglyoxal (MGO) is considered to be one of the vital components responsible for the anti-bacterial activity of Leptospermum spp. (Manuka) honey. While many studies have demonstrated a dose-dependent antibacterial activity for MGO in vitro, from a therapeutic viewpoint, it is also important to confirm its release from Manuka honey and also from Manuka honey-based formulations. This study is the first to report on the release profile of MGO from five commercial products containing Manuka honey using a Franz diffusion cell and High-Performance Liquid Chromatography (HPLC) analysis. The release of MGO expressed as percentage release of MGO content at baseline was monitored over a 12 h period and found to be 99.49 and 98.05% from an artificial honey matrix and NZ Manuka honey, respectively. For the investigated formulations, a time-dependent % MGO release between 85% and 97.18% was noted over the 12 h study period.
format Online
Article
Text
id pubmed-10051060
institution National Center for Biotechnology Information
language English
publishDate 2023
publisher MDPI
record_format MEDLINE/PubMed
spelling pubmed-100510602023-03-30 Monitoring the Release of Methylglyoxal (MGO) from Honey and Honey-Based Formulations Hossain, Md Lokman Lim, Lee Yong Hammer, Katherine Hettiarachchi, Dhanushka Locher, Cornelia Molecules Article Methylglyoxal (MGO) is considered to be one of the vital components responsible for the anti-bacterial activity of Leptospermum spp. (Manuka) honey. While many studies have demonstrated a dose-dependent antibacterial activity for MGO in vitro, from a therapeutic viewpoint, it is also important to confirm its release from Manuka honey and also from Manuka honey-based formulations. This study is the first to report on the release profile of MGO from five commercial products containing Manuka honey using a Franz diffusion cell and High-Performance Liquid Chromatography (HPLC) analysis. The release of MGO expressed as percentage release of MGO content at baseline was monitored over a 12 h period and found to be 99.49 and 98.05% from an artificial honey matrix and NZ Manuka honey, respectively. For the investigated formulations, a time-dependent % MGO release between 85% and 97.18% was noted over the 12 h study period. MDPI 2023-03-22 /pmc/articles/PMC10051060/ /pubmed/36985830 http://dx.doi.org/10.3390/molecules28062858 Text en © 2023 by the authors. https://creativecommons.org/licenses/by/4.0/Licensee MDPI, Basel, Switzerland. This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution (CC BY) license (https://creativecommons.org/licenses/by/4.0/).
spellingShingle Article
Hossain, Md Lokman
Lim, Lee Yong
Hammer, Katherine
Hettiarachchi, Dhanushka
Locher, Cornelia
Monitoring the Release of Methylglyoxal (MGO) from Honey and Honey-Based Formulations
title Monitoring the Release of Methylglyoxal (MGO) from Honey and Honey-Based Formulations
title_full Monitoring the Release of Methylglyoxal (MGO) from Honey and Honey-Based Formulations
title_fullStr Monitoring the Release of Methylglyoxal (MGO) from Honey and Honey-Based Formulations
title_full_unstemmed Monitoring the Release of Methylglyoxal (MGO) from Honey and Honey-Based Formulations
title_short Monitoring the Release of Methylglyoxal (MGO) from Honey and Honey-Based Formulations
title_sort monitoring the release of methylglyoxal (mgo) from honey and honey-based formulations
topic Article
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10051060/
https://www.ncbi.nlm.nih.gov/pubmed/36985830
http://dx.doi.org/10.3390/molecules28062858
work_keys_str_mv AT hossainmdlokman monitoringthereleaseofmethylglyoxalmgofromhoneyandhoneybasedformulations
AT limleeyong monitoringthereleaseofmethylglyoxalmgofromhoneyandhoneybasedformulations
AT hammerkatherine monitoringthereleaseofmethylglyoxalmgofromhoneyandhoneybasedformulations
AT hettiarachchidhanushka monitoringthereleaseofmethylglyoxalmgofromhoneyandhoneybasedformulations
AT lochercornelia monitoringthereleaseofmethylglyoxalmgofromhoneyandhoneybasedformulations