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Natural Products and Their Derivatives as Inhibitors of the DNA Repair Enzyme Tyrosyl-DNA Phosphodiesterase 1

Tyrosyl-DNA phosphodiesterase 1 (TDP1) is an important repair enzyme that removes various covalent adducts from the 3′ end of DNA. Particularly, covalent complexes of topoisomerase 1 (TOP1) with DNA stabilized by DNA damage or by various chemical agents are an examples of such adducts. Anticancer dr...

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Detalles Bibliográficos
Autores principales:	Zakharenko, Alexandra L., Luzina, Olga A., Chepanova, Arina A., Dyrkheeva, Nadezhda S., Salakhutdinov, Nariman F., Lavrik, Olga I.
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	MDPI 2023
Materias:	Review
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10051138/ https://www.ncbi.nlm.nih.gov/pubmed/36982848 http://dx.doi.org/10.3390/ijms24065781

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