The Association of Four Natural Molecules—EGCG, Folic Acid, Vitamin B12, and HA—To Counteract HPV Cervical Lesions: A Case Report

Precancerous lesions of the uterine cervix, due to HPV infections, are still today a great medical challenge. This clinical case highlighted the effectiveness of epigallocatechin gallate (EGCG), vitamin B12, folic acid, and hyaluronic acid (HA) in counteracting HPV lesions in a 39-year-old patient w...

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Autores principales: Grandi, Giovanni, Botticelli, Laura, Fraia, Pietro Di, Babalini, Carla, Masini, Meris, Unfer, Vittorio
Formato: Online Artículo Texto
Lenguaje:English
Publicado: MDPI 2023
Materias:
Case Report
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10051187/
https://www.ncbi.nlm.nih.gov/pubmed/36983748
http://dx.doi.org/10.3390/jpm13030567
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author Grandi, Giovanni
Botticelli, Laura
Fraia, Pietro Di
Babalini, Carla
Masini, Meris
Unfer, Vittorio
author_facet Grandi, Giovanni
Botticelli, Laura
Fraia, Pietro Di
Babalini, Carla
Masini, Meris
Unfer, Vittorio
author_sort Grandi, Giovanni
collection PubMed
description Precancerous lesions of the uterine cervix, due to HPV infections, are still today a great medical challenge. This clinical case highlighted the effectiveness of epigallocatechin gallate (EGCG), vitamin B12, folic acid, and hyaluronic acid (HA) in counteracting HPV lesions in a 39-year-old patient with a long history of viral persistence, cervical lesions of various degree, and several unsuccessful surgical approaches. After eight weeks of treatment, both the histological and cytological analyses revealed only a chronic cervicitis without any malignant lesions or cellular dysplasia, thus reducing the urgency of an invasive surgery, a total hysterectomy.
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spelling pubmed-100511872023-03-30 The Association of Four Natural Molecules—EGCG, Folic Acid, Vitamin B12, and HA—To Counteract HPV Cervical Lesions: A Case Report Grandi, Giovanni Botticelli, Laura Fraia, Pietro Di Babalini, Carla Masini, Meris Unfer, Vittorio J Pers Med Case Report Precancerous lesions of the uterine cervix, due to HPV infections, are still today a great medical challenge. This clinical case highlighted the effectiveness of epigallocatechin gallate (EGCG), vitamin B12, folic acid, and hyaluronic acid (HA) in counteracting HPV lesions in a 39-year-old patient with a long history of viral persistence, cervical lesions of various degree, and several unsuccessful surgical approaches. After eight weeks of treatment, both the histological and cytological analyses revealed only a chronic cervicitis without any malignant lesions or cellular dysplasia, thus reducing the urgency of an invasive surgery, a total hysterectomy. MDPI 2023-03-22 /pmc/articles/PMC10051187/ /pubmed/36983748 http://dx.doi.org/10.3390/jpm13030567 Text en © 2023 by the authors. https://creativecommons.org/licenses/by/4.0/Licensee MDPI, Basel, Switzerland. This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution (CC BY) license (https://creativecommons.org/licenses/by/4.0/).
spellingShingle Case Report
Grandi, Giovanni
Botticelli, Laura
Fraia, Pietro Di
Babalini, Carla
Masini, Meris
Unfer, Vittorio
The Association of Four Natural Molecules—EGCG, Folic Acid, Vitamin B12, and HA—To Counteract HPV Cervical Lesions: A Case Report
title The Association of Four Natural Molecules—EGCG, Folic Acid, Vitamin B12, and HA—To Counteract HPV Cervical Lesions: A Case Report
title_full The Association of Four Natural Molecules—EGCG, Folic Acid, Vitamin B12, and HA—To Counteract HPV Cervical Lesions: A Case Report
title_fullStr The Association of Four Natural Molecules—EGCG, Folic Acid, Vitamin B12, and HA—To Counteract HPV Cervical Lesions: A Case Report
title_full_unstemmed The Association of Four Natural Molecules—EGCG, Folic Acid, Vitamin B12, and HA—To Counteract HPV Cervical Lesions: A Case Report
title_short The Association of Four Natural Molecules—EGCG, Folic Acid, Vitamin B12, and HA—To Counteract HPV Cervical Lesions: A Case Report
title_sort association of four natural molecules—egcg, folic acid, vitamin b12, and ha—to counteract hpv cervical lesions: a case report
topic Case Report
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10051187/
https://www.ncbi.nlm.nih.gov/pubmed/36983748
http://dx.doi.org/10.3390/jpm13030567
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