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Neuroinflammation in Parkinson’s Disease: From Gene to Clinic: A Systematic Review

Parkinson’s disease is a neurodegenerative disease whose progression and clinical characteristics have a close bidirectional and multilevel relationship with the process of neuroinflammation. In this context, it is necessary to understand the mechanisms involved in this neuroinflammation–PD link. Th...

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Detalles Bibliográficos
Autores principales: Castillo-Rangel, Carlos, Marin, Gerardo, Hernández-Contreras, Karla Aketzalli, Vichi-Ramírez, Micheel Merari, Zarate-Calderon, Cristofer, Torres-Pineda, Osvaldo, Diaz-Chiguer, Dylan L., De la Mora González, David, Gómez Apo, Erick, Teco-Cortes, Javier Alejandro, Santos-Paez, Flor de María, Coello-Torres, María de los Ángeles, Baldoncini, Matías, Reyes Soto, Gervith, Aranda-Abreu, Gonzalo Emiliano, García, Luis I.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: MDPI 2023
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10051221/
https://www.ncbi.nlm.nih.gov/pubmed/36982866
http://dx.doi.org/10.3390/ijms24065792
Descripción
Sumario:Parkinson’s disease is a neurodegenerative disease whose progression and clinical characteristics have a close bidirectional and multilevel relationship with the process of neuroinflammation. In this context, it is necessary to understand the mechanisms involved in this neuroinflammation–PD link. This systematic search was, hereby, conducted with a focus on the four levels where alterations associated with neuroinflammation in PD have been described (genetic, cellular, histopathological and clinical-behavioral) by consulting the PubMed, Google Scholar, Scielo and Redalyc search engines, including clinical studies, review articles, book chapters and case studies. Initially, 585,772 articles were included, and, after applying the inclusion and exclusion criteria, 84 articles were obtained that contained information about the multilevel association of neuroinflammation with alterations in gene, molecular, cellular, tissue and neuroanatomical expression as well as clinical-behavioral manifestations in PD.