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Neuroinflammation in Parkinson’s Disease: From Gene to Clinic: A Systematic Review

Parkinson’s disease is a neurodegenerative disease whose progression and clinical characteristics have a close bidirectional and multilevel relationship with the process of neuroinflammation. In this context, it is necessary to understand the mechanisms involved in this neuroinflammation–PD link. Th...

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Autores principales: Castillo-Rangel, Carlos, Marin, Gerardo, Hernández-Contreras, Karla Aketzalli, Vichi-Ramírez, Micheel Merari, Zarate-Calderon, Cristofer, Torres-Pineda, Osvaldo, Diaz-Chiguer, Dylan L., De la Mora González, David, Gómez Apo, Erick, Teco-Cortes, Javier Alejandro, Santos-Paez, Flor de María, Coello-Torres, María de los Ángeles, Baldoncini, Matías, Reyes Soto, Gervith, Aranda-Abreu, Gonzalo Emiliano, García, Luis I.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: MDPI 2023
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10051221/
https://www.ncbi.nlm.nih.gov/pubmed/36982866
http://dx.doi.org/10.3390/ijms24065792
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author Castillo-Rangel, Carlos
Marin, Gerardo
Hernández-Contreras, Karla Aketzalli
Vichi-Ramírez, Micheel Merari
Zarate-Calderon, Cristofer
Torres-Pineda, Osvaldo
Diaz-Chiguer, Dylan L.
De la Mora González, David
Gómez Apo, Erick
Teco-Cortes, Javier Alejandro
Santos-Paez, Flor de María
Coello-Torres, María de los Ángeles
Baldoncini, Matías
Reyes Soto, Gervith
Aranda-Abreu, Gonzalo Emiliano
García, Luis I.
author_facet Castillo-Rangel, Carlos
Marin, Gerardo
Hernández-Contreras, Karla Aketzalli
Vichi-Ramírez, Micheel Merari
Zarate-Calderon, Cristofer
Torres-Pineda, Osvaldo
Diaz-Chiguer, Dylan L.
De la Mora González, David
Gómez Apo, Erick
Teco-Cortes, Javier Alejandro
Santos-Paez, Flor de María
Coello-Torres, María de los Ángeles
Baldoncini, Matías
Reyes Soto, Gervith
Aranda-Abreu, Gonzalo Emiliano
García, Luis I.
author_sort Castillo-Rangel, Carlos
collection PubMed
description Parkinson’s disease is a neurodegenerative disease whose progression and clinical characteristics have a close bidirectional and multilevel relationship with the process of neuroinflammation. In this context, it is necessary to understand the mechanisms involved in this neuroinflammation–PD link. This systematic search was, hereby, conducted with a focus on the four levels where alterations associated with neuroinflammation in PD have been described (genetic, cellular, histopathological and clinical-behavioral) by consulting the PubMed, Google Scholar, Scielo and Redalyc search engines, including clinical studies, review articles, book chapters and case studies. Initially, 585,772 articles were included, and, after applying the inclusion and exclusion criteria, 84 articles were obtained that contained information about the multilevel association of neuroinflammation with alterations in gene, molecular, cellular, tissue and neuroanatomical expression as well as clinical-behavioral manifestations in PD.
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spelling pubmed-100512212023-03-30 Neuroinflammation in Parkinson’s Disease: From Gene to Clinic: A Systematic Review Castillo-Rangel, Carlos Marin, Gerardo Hernández-Contreras, Karla Aketzalli Vichi-Ramírez, Micheel Merari Zarate-Calderon, Cristofer Torres-Pineda, Osvaldo Diaz-Chiguer, Dylan L. De la Mora González, David Gómez Apo, Erick Teco-Cortes, Javier Alejandro Santos-Paez, Flor de María Coello-Torres, María de los Ángeles Baldoncini, Matías Reyes Soto, Gervith Aranda-Abreu, Gonzalo Emiliano García, Luis I. Int J Mol Sci Review Parkinson’s disease is a neurodegenerative disease whose progression and clinical characteristics have a close bidirectional and multilevel relationship with the process of neuroinflammation. In this context, it is necessary to understand the mechanisms involved in this neuroinflammation–PD link. This systematic search was, hereby, conducted with a focus on the four levels where alterations associated with neuroinflammation in PD have been described (genetic, cellular, histopathological and clinical-behavioral) by consulting the PubMed, Google Scholar, Scielo and Redalyc search engines, including clinical studies, review articles, book chapters and case studies. Initially, 585,772 articles were included, and, after applying the inclusion and exclusion criteria, 84 articles were obtained that contained information about the multilevel association of neuroinflammation with alterations in gene, molecular, cellular, tissue and neuroanatomical expression as well as clinical-behavioral manifestations in PD. MDPI 2023-03-17 /pmc/articles/PMC10051221/ /pubmed/36982866 http://dx.doi.org/10.3390/ijms24065792 Text en © 2023 by the authors. https://creativecommons.org/licenses/by/4.0/Licensee MDPI, Basel, Switzerland. This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution (CC BY) license (https://creativecommons.org/licenses/by/4.0/).
spellingShingle Review
Castillo-Rangel, Carlos
Marin, Gerardo
Hernández-Contreras, Karla Aketzalli
Vichi-Ramírez, Micheel Merari
Zarate-Calderon, Cristofer
Torres-Pineda, Osvaldo
Diaz-Chiguer, Dylan L.
De la Mora González, David
Gómez Apo, Erick
Teco-Cortes, Javier Alejandro
Santos-Paez, Flor de María
Coello-Torres, María de los Ángeles
Baldoncini, Matías
Reyes Soto, Gervith
Aranda-Abreu, Gonzalo Emiliano
García, Luis I.
Neuroinflammation in Parkinson’s Disease: From Gene to Clinic: A Systematic Review
title Neuroinflammation in Parkinson’s Disease: From Gene to Clinic: A Systematic Review
title_full Neuroinflammation in Parkinson’s Disease: From Gene to Clinic: A Systematic Review
title_fullStr Neuroinflammation in Parkinson’s Disease: From Gene to Clinic: A Systematic Review
title_full_unstemmed Neuroinflammation in Parkinson’s Disease: From Gene to Clinic: A Systematic Review
title_short Neuroinflammation in Parkinson’s Disease: From Gene to Clinic: A Systematic Review
title_sort neuroinflammation in parkinson’s disease: from gene to clinic: a systematic review
topic Review
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10051221/
https://www.ncbi.nlm.nih.gov/pubmed/36982866
http://dx.doi.org/10.3390/ijms24065792
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