Generation of a p21 Reporter Mouse and Its Use to Identify and Eliminate p21(high) Cells In Vivo

P21 and p16 have been identified as inducers of senescence. Many transgenic mouse models have been developed to target cells expressing high levels of p16(Ink4a) (p16(high)) and investigate their potential contribution to tissue dysfunction in aging, obesity, and other pathological conditions. Howev...

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Detalles Bibliográficos
Autores principales: Yi, Zimei, Ren, Le, Wei, Yu, Chen, Siyi, Zhao, Jiechen, Zhu, Jiayu, Wu, Junhua
Formato: Online Artículo Texto
Lenguaje:English
Publicado: MDPI 2023
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10051249/
https://www.ncbi.nlm.nih.gov/pubmed/36982640
http://dx.doi.org/10.3390/ijms24065565

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10051249/
https://www.ncbi.nlm.nih.gov/pubmed/36982640
http://dx.doi.org/10.3390/ijms24065565

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