Cargando…

Contribution of Blood Vessel Activation, Remodeling and Barrier Function to Inflammatory Bowel Diseases

Inflammatory bowel diseases (IBDs) consist of a group of chronic inflammatory disorders with a complex etiology, which represent a clinical challenge due to their often therapy-refractory nature. In IBD, inflammation of the intestinal mucosa is characterized by strong and sustained leukocyte infiltr...

Descripción completa

Detalles Bibliográficos
Autores principales: Britzen-Laurent, Nathalie, Weidinger, Carl, Stürzl, Michael
Formato: Online Artículo Texto
Lenguaje:English
Publicado: MDPI 2023
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10051397/
https://www.ncbi.nlm.nih.gov/pubmed/36982601
http://dx.doi.org/10.3390/ijms24065517
_version_ 1785014876359360512
author Britzen-Laurent, Nathalie
Weidinger, Carl
Stürzl, Michael
author_facet Britzen-Laurent, Nathalie
Weidinger, Carl
Stürzl, Michael
author_sort Britzen-Laurent, Nathalie
collection PubMed
description Inflammatory bowel diseases (IBDs) consist of a group of chronic inflammatory disorders with a complex etiology, which represent a clinical challenge due to their often therapy-refractory nature. In IBD, inflammation of the intestinal mucosa is characterized by strong and sustained leukocyte infiltration, resulting in the loss of epithelial barrier function and subsequent tissue destruction. This is accompanied by the activation and the massive remodeling of mucosal micro-vessels. The role of the gut vasculature in the induction and perpetuation of mucosal inflammation is receiving increasing recognition. While the vascular barrier is considered to offer protection against bacterial translocation and sepsis after the breakdown of the epithelial barrier, endothelium activation and angiogenesis are thought to promote inflammation. The present review examines the respective pathological contributions of the different phenotypical changes observed in the microvascular endothelium during IBD, and provides an overview of potential vessel-specific targeted therapy options for the treatment of IBD.
format Online
Article
Text
id pubmed-10051397
institution National Center for Biotechnology Information
language English
publishDate 2023
publisher MDPI
record_format MEDLINE/PubMed
spelling pubmed-100513972023-03-30 Contribution of Blood Vessel Activation, Remodeling and Barrier Function to Inflammatory Bowel Diseases Britzen-Laurent, Nathalie Weidinger, Carl Stürzl, Michael Int J Mol Sci Review Inflammatory bowel diseases (IBDs) consist of a group of chronic inflammatory disorders with a complex etiology, which represent a clinical challenge due to their often therapy-refractory nature. In IBD, inflammation of the intestinal mucosa is characterized by strong and sustained leukocyte infiltration, resulting in the loss of epithelial barrier function and subsequent tissue destruction. This is accompanied by the activation and the massive remodeling of mucosal micro-vessels. The role of the gut vasculature in the induction and perpetuation of mucosal inflammation is receiving increasing recognition. While the vascular barrier is considered to offer protection against bacterial translocation and sepsis after the breakdown of the epithelial barrier, endothelium activation and angiogenesis are thought to promote inflammation. The present review examines the respective pathological contributions of the different phenotypical changes observed in the microvascular endothelium during IBD, and provides an overview of potential vessel-specific targeted therapy options for the treatment of IBD. MDPI 2023-03-14 /pmc/articles/PMC10051397/ /pubmed/36982601 http://dx.doi.org/10.3390/ijms24065517 Text en © 2023 by the authors. https://creativecommons.org/licenses/by/4.0/Licensee MDPI, Basel, Switzerland. This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution (CC BY) license (https://creativecommons.org/licenses/by/4.0/).
spellingShingle Review
Britzen-Laurent, Nathalie
Weidinger, Carl
Stürzl, Michael
Contribution of Blood Vessel Activation, Remodeling and Barrier Function to Inflammatory Bowel Diseases
title Contribution of Blood Vessel Activation, Remodeling and Barrier Function to Inflammatory Bowel Diseases
title_full Contribution of Blood Vessel Activation, Remodeling and Barrier Function to Inflammatory Bowel Diseases
title_fullStr Contribution of Blood Vessel Activation, Remodeling and Barrier Function to Inflammatory Bowel Diseases
title_full_unstemmed Contribution of Blood Vessel Activation, Remodeling and Barrier Function to Inflammatory Bowel Diseases
title_short Contribution of Blood Vessel Activation, Remodeling and Barrier Function to Inflammatory Bowel Diseases
title_sort contribution of blood vessel activation, remodeling and barrier function to inflammatory bowel diseases
topic Review
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10051397/
https://www.ncbi.nlm.nih.gov/pubmed/36982601
http://dx.doi.org/10.3390/ijms24065517
work_keys_str_mv AT britzenlaurentnathalie contributionofbloodvesselactivationremodelingandbarrierfunctiontoinflammatoryboweldiseases
AT weidingercarl contributionofbloodvesselactivationremodelingandbarrierfunctiontoinflammatoryboweldiseases
AT sturzlmichael contributionofbloodvesselactivationremodelingandbarrierfunctiontoinflammatoryboweldiseases