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Intracellular Delivery of Itaconate by Metal–Organic Framework-Anchored Hydrogel Microspheres for Osteoarthritis Therapy

Treatment of osteoarthritis (OA) remains a significant clinical challenge. Itaconate (IA), an emerging regulator of intracellular inflammation and oxidative stress, may potentially be harnessed to treat OA. However, the short joint residence time, inefficient drug delivery, and cell-impermeable prop...

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Detalles Bibliográficos
Autores principales:	Yu, Han, Ren, Peng, Pan, Xuekang, Zhang, Xinyu, Ma, Jun, Chen, Jiayi, Sheng, Jian, Luo, Huanhuan, Lu, Huigen, Chen, Gang
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	MDPI 2023
Materias:	Article
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10051475/ https://www.ncbi.nlm.nih.gov/pubmed/36986584 http://dx.doi.org/10.3390/pharmaceutics15030724

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