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Prolonged SARS-CoV-2 Infection and Organizing Pneumonia in a Patient with Follicular Lymphoma, Treated with Obinutuzumab—Challenging Recognition and Treatment

A Severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) causing coronavirus disease 2019 (COVID-19) led to a pandemic outbreak in 2019. COVID-19’s course and its treatment in immunocompromised patients are uncertain. Furthermore, there is a possibility of protracted SARS-CoV-2 infection and t...

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Autores principales: Łyżwa, E., Sobiecka, M., Lewandowska, K., Siemion-Szcześniak, I., Barańska, I., Klatt, M., Langfort, R., Szturmowicz, M., Tomkowski, W.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: MDPI 2023
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10051526/
https://www.ncbi.nlm.nih.gov/pubmed/36992402
http://dx.doi.org/10.3390/v15030693
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author Łyżwa, E.
Sobiecka, M.
Lewandowska, K.
Siemion-Szcześniak, I.
Barańska, I.
Klatt, M.
Langfort, R.
Szturmowicz, M.
Tomkowski, W.
author_facet Łyżwa, E.
Sobiecka, M.
Lewandowska, K.
Siemion-Szcześniak, I.
Barańska, I.
Klatt, M.
Langfort, R.
Szturmowicz, M.
Tomkowski, W.
author_sort Łyżwa, E.
collection PubMed
description A Severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) causing coronavirus disease 2019 (COVID-19) led to a pandemic outbreak in 2019. COVID-19’s course and its treatment in immunocompromised patients are uncertain. Furthermore, there is a possibility of protracted SARS-CoV-2 infection and the need for repeated antiviral treatment. Monoclonal antibodies against CD20, which are used, among other things, in the therapy of chronic lymphocytic leukaemia and follicular lymphoma, can induct immunosuppression. We present a case report of a patient with follicular lymphoma, treated with obinutuzumab, who was diagnosed with prolonged, ongoing SARS-CoV-2 infection and related organizing pneumonia. The recognition and the treatment were challenging which makes this case noteworthy. Antiviral therapy with several medications was administrated to our patient and their temporary, positive effect was observed. Moreover, high-dose intravenous immunoglobulin was applied, because slowly decreasing IgM and IgG levels were observed. The patient also received standard treatment of organizing pneumonia. We believe that such a complex approach can create an opportunity for recovery. Physicians should be conscious of the course and treatment possibilities facing similar cases.
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spelling pubmed-100515262023-03-30 Prolonged SARS-CoV-2 Infection and Organizing Pneumonia in a Patient with Follicular Lymphoma, Treated with Obinutuzumab—Challenging Recognition and Treatment Łyżwa, E. Sobiecka, M. Lewandowska, K. Siemion-Szcześniak, I. Barańska, I. Klatt, M. Langfort, R. Szturmowicz, M. Tomkowski, W. Viruses Case Report A Severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) causing coronavirus disease 2019 (COVID-19) led to a pandemic outbreak in 2019. COVID-19’s course and its treatment in immunocompromised patients are uncertain. Furthermore, there is a possibility of protracted SARS-CoV-2 infection and the need for repeated antiviral treatment. Monoclonal antibodies against CD20, which are used, among other things, in the therapy of chronic lymphocytic leukaemia and follicular lymphoma, can induct immunosuppression. We present a case report of a patient with follicular lymphoma, treated with obinutuzumab, who was diagnosed with prolonged, ongoing SARS-CoV-2 infection and related organizing pneumonia. The recognition and the treatment were challenging which makes this case noteworthy. Antiviral therapy with several medications was administrated to our patient and their temporary, positive effect was observed. Moreover, high-dose intravenous immunoglobulin was applied, because slowly decreasing IgM and IgG levels were observed. The patient also received standard treatment of organizing pneumonia. We believe that such a complex approach can create an opportunity for recovery. Physicians should be conscious of the course and treatment possibilities facing similar cases. MDPI 2023-03-07 /pmc/articles/PMC10051526/ /pubmed/36992402 http://dx.doi.org/10.3390/v15030693 Text en © 2023 by the authors. https://creativecommons.org/licenses/by/4.0/Licensee MDPI, Basel, Switzerland. This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution (CC BY) license (https://creativecommons.org/licenses/by/4.0/).
spellingShingle Case Report
Łyżwa, E.
Sobiecka, M.
Lewandowska, K.
Siemion-Szcześniak, I.
Barańska, I.
Klatt, M.
Langfort, R.
Szturmowicz, M.
Tomkowski, W.
Prolonged SARS-CoV-2 Infection and Organizing Pneumonia in a Patient with Follicular Lymphoma, Treated with Obinutuzumab—Challenging Recognition and Treatment
title Prolonged SARS-CoV-2 Infection and Organizing Pneumonia in a Patient with Follicular Lymphoma, Treated with Obinutuzumab—Challenging Recognition and Treatment
title_full Prolonged SARS-CoV-2 Infection and Organizing Pneumonia in a Patient with Follicular Lymphoma, Treated with Obinutuzumab—Challenging Recognition and Treatment
title_fullStr Prolonged SARS-CoV-2 Infection and Organizing Pneumonia in a Patient with Follicular Lymphoma, Treated with Obinutuzumab—Challenging Recognition and Treatment
title_full_unstemmed Prolonged SARS-CoV-2 Infection and Organizing Pneumonia in a Patient with Follicular Lymphoma, Treated with Obinutuzumab—Challenging Recognition and Treatment
title_short Prolonged SARS-CoV-2 Infection and Organizing Pneumonia in a Patient with Follicular Lymphoma, Treated with Obinutuzumab—Challenging Recognition and Treatment
title_sort prolonged sars-cov-2 infection and organizing pneumonia in a patient with follicular lymphoma, treated with obinutuzumab—challenging recognition and treatment
topic Case Report
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10051526/
https://www.ncbi.nlm.nih.gov/pubmed/36992402
http://dx.doi.org/10.3390/v15030693
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