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Ru(II) Complex Grafted Ti(3)C(2)T(x) MXene Nano Sheet with Photothermal/Photodynamic Synergistic Antibacterial Activity

For a long time, the emergence of microbial drug resistance due to the abuse of antibiotics has greatly reduced the therapeutic effect of many existing antibiotics. This makes the development of new antimicrobial materials urgent. Light-assisted antimicrobial therapy is an alternative to antibiotic...

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Detalles Bibliográficos
Autores principales: Liu, Xiaofang, Xie, Hongchi, Zhuo, Shi, Zhou, Yuanhong, Selim, Mohamed S., Chen, Xiang, Hao, Zhifeng
Formato: Online Artículo Texto
Lenguaje:English
Publicado: MDPI 2023
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10051588/
https://www.ncbi.nlm.nih.gov/pubmed/36985852
http://dx.doi.org/10.3390/nano13060958
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author Liu, Xiaofang
Xie, Hongchi
Zhuo, Shi
Zhou, Yuanhong
Selim, Mohamed S.
Chen, Xiang
Hao, Zhifeng
author_facet Liu, Xiaofang
Xie, Hongchi
Zhuo, Shi
Zhou, Yuanhong
Selim, Mohamed S.
Chen, Xiang
Hao, Zhifeng
author_sort Liu, Xiaofang
collection PubMed
description For a long time, the emergence of microbial drug resistance due to the abuse of antibiotics has greatly reduced the therapeutic effect of many existing antibiotics. This makes the development of new antimicrobial materials urgent. Light-assisted antimicrobial therapy is an alternative to antibiotic therapy due to its high antimicrobial efficiency and non-resistance. Here, we develop a nanocomposite material (Ru@MXene) which is based on Ru(bpy)(dcb)(2+) connected to MXene nanosheets by ester bonding as a photothermal/photodynamic synergistic antibacterial material. The obtained Ru@MXene nanocomposites exhibit a strengthened antimicrobial capacity compared to Ru or MXene alone, which can be attributed to the higher reactive oxygen species (ROS) yield and the thermal effect. Once exposed to a xenon lamp, Ru@MXene promptly achieved almost 100% bactericidal activity against Escherichia coli (200 μg/mL) and Staphylococcus aureus (100 μg/mL). This is ascribed to its synergistic photothermal therapy (PTT) and photodynamic therapy (PDT) capabilities. Consequently, the innovative Ru@MXene can be a prospective non-drug antimicrobial therapy that avoids antibiotic resistance in practice. Notably, this high-efficiency PTT/PDT synergistic antimicrobial material by bonding Ru complexes to MXene is the first such reported model. However, the toxic effects of Ru@MXene materials need to be studied to evaluate them for further medical applications.
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spelling pubmed-100515882023-03-30 Ru(II) Complex Grafted Ti(3)C(2)T(x) MXene Nano Sheet with Photothermal/Photodynamic Synergistic Antibacterial Activity Liu, Xiaofang Xie, Hongchi Zhuo, Shi Zhou, Yuanhong Selim, Mohamed S. Chen, Xiang Hao, Zhifeng Nanomaterials (Basel) Article For a long time, the emergence of microbial drug resistance due to the abuse of antibiotics has greatly reduced the therapeutic effect of many existing antibiotics. This makes the development of new antimicrobial materials urgent. Light-assisted antimicrobial therapy is an alternative to antibiotic therapy due to its high antimicrobial efficiency and non-resistance. Here, we develop a nanocomposite material (Ru@MXene) which is based on Ru(bpy)(dcb)(2+) connected to MXene nanosheets by ester bonding as a photothermal/photodynamic synergistic antibacterial material. The obtained Ru@MXene nanocomposites exhibit a strengthened antimicrobial capacity compared to Ru or MXene alone, which can be attributed to the higher reactive oxygen species (ROS) yield and the thermal effect. Once exposed to a xenon lamp, Ru@MXene promptly achieved almost 100% bactericidal activity against Escherichia coli (200 μg/mL) and Staphylococcus aureus (100 μg/mL). This is ascribed to its synergistic photothermal therapy (PTT) and photodynamic therapy (PDT) capabilities. Consequently, the innovative Ru@MXene can be a prospective non-drug antimicrobial therapy that avoids antibiotic resistance in practice. Notably, this high-efficiency PTT/PDT synergistic antimicrobial material by bonding Ru complexes to MXene is the first such reported model. However, the toxic effects of Ru@MXene materials need to be studied to evaluate them for further medical applications. MDPI 2023-03-07 /pmc/articles/PMC10051588/ /pubmed/36985852 http://dx.doi.org/10.3390/nano13060958 Text en © 2023 by the authors. https://creativecommons.org/licenses/by/4.0/Licensee MDPI, Basel, Switzerland. This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution (CC BY) license (https://creativecommons.org/licenses/by/4.0/).
spellingShingle Article
Liu, Xiaofang
Xie, Hongchi
Zhuo, Shi
Zhou, Yuanhong
Selim, Mohamed S.
Chen, Xiang
Hao, Zhifeng
Ru(II) Complex Grafted Ti(3)C(2)T(x) MXene Nano Sheet with Photothermal/Photodynamic Synergistic Antibacterial Activity
title Ru(II) Complex Grafted Ti(3)C(2)T(x) MXene Nano Sheet with Photothermal/Photodynamic Synergistic Antibacterial Activity
title_full Ru(II) Complex Grafted Ti(3)C(2)T(x) MXene Nano Sheet with Photothermal/Photodynamic Synergistic Antibacterial Activity
title_fullStr Ru(II) Complex Grafted Ti(3)C(2)T(x) MXene Nano Sheet with Photothermal/Photodynamic Synergistic Antibacterial Activity
title_full_unstemmed Ru(II) Complex Grafted Ti(3)C(2)T(x) MXene Nano Sheet with Photothermal/Photodynamic Synergistic Antibacterial Activity
title_short Ru(II) Complex Grafted Ti(3)C(2)T(x) MXene Nano Sheet with Photothermal/Photodynamic Synergistic Antibacterial Activity
title_sort ru(ii) complex grafted ti(3)c(2)t(x) mxene nano sheet with photothermal/photodynamic synergistic antibacterial activity
topic Article
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10051588/
https://www.ncbi.nlm.nih.gov/pubmed/36985852
http://dx.doi.org/10.3390/nano13060958
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