Recent Development of Rhenium-Based Materials in the Application of Diagnosis and Tumor Therapy

Rhenium (Re) is widely used in the diagnosis and treatment of cancer due to its unique physical and chemical properties. Re has more valence electrons in its outer shell, allowing it to exist in a variety of oxidation states and to form different geometric configurations with many different ligands....

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Autores principales: Qi, Qingwen, Wang, Qian, Li, Yuhao, Silva, Dionisio Zaldivar, Ruiz, Maria Eliana Lanio, Ouyang, Ruizhuo, Liu, Baolin, Miao, Yuqing
Formato: Online Artículo Texto
Lenguaje:English
Publicado: MDPI 2023
Materias:
Review
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10051626/
https://www.ncbi.nlm.nih.gov/pubmed/36985704
http://dx.doi.org/10.3390/molecules28062733
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author Qi, Qingwen
Wang, Qian
Li, Yuhao
Silva, Dionisio Zaldivar
Ruiz, Maria Eliana Lanio
Ouyang, Ruizhuo
Liu, Baolin
Miao, Yuqing
author_facet Qi, Qingwen
Wang, Qian
Li, Yuhao
Silva, Dionisio Zaldivar
Ruiz, Maria Eliana Lanio
Ouyang, Ruizhuo
Liu, Baolin
Miao, Yuqing
author_sort Qi, Qingwen
collection PubMed
description Rhenium (Re) is widely used in the diagnosis and treatment of cancer due to its unique physical and chemical properties. Re has more valence electrons in its outer shell, allowing it to exist in a variety of oxidation states and to form different geometric configurations with many different ligands. The luminescence properties, lipophilicity, and cytotoxicity of complexes can be adjusted by changing the ligand of Re. This article mainly reviews the development of radionuclide (188)Re in radiotherapy and some innovative applications of Re as well as the different therapeutic approaches and imaging techniques used in cancer therapy. In addition, the current application and future challenges and opportunities of Re are also discussed.
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spelling pubmed-100516262023-03-30 Recent Development of Rhenium-Based Materials in the Application of Diagnosis and Tumor Therapy Qi, Qingwen Wang, Qian Li, Yuhao Silva, Dionisio Zaldivar Ruiz, Maria Eliana Lanio Ouyang, Ruizhuo Liu, Baolin Miao, Yuqing Molecules Review Rhenium (Re) is widely used in the diagnosis and treatment of cancer due to its unique physical and chemical properties. Re has more valence electrons in its outer shell, allowing it to exist in a variety of oxidation states and to form different geometric configurations with many different ligands. The luminescence properties, lipophilicity, and cytotoxicity of complexes can be adjusted by changing the ligand of Re. This article mainly reviews the development of radionuclide (188)Re in radiotherapy and some innovative applications of Re as well as the different therapeutic approaches and imaging techniques used in cancer therapy. In addition, the current application and future challenges and opportunities of Re are also discussed. MDPI 2023-03-17 /pmc/articles/PMC10051626/ /pubmed/36985704 http://dx.doi.org/10.3390/molecules28062733 Text en © 2023 by the authors. https://creativecommons.org/licenses/by/4.0/Licensee MDPI, Basel, Switzerland. This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution (CC BY) license (https://creativecommons.org/licenses/by/4.0/).
spellingShingle Review
Qi, Qingwen
Wang, Qian
Li, Yuhao
Silva, Dionisio Zaldivar
Ruiz, Maria Eliana Lanio
Ouyang, Ruizhuo
Liu, Baolin
Miao, Yuqing
Recent Development of Rhenium-Based Materials in the Application of Diagnosis and Tumor Therapy
title Recent Development of Rhenium-Based Materials in the Application of Diagnosis and Tumor Therapy
title_full Recent Development of Rhenium-Based Materials in the Application of Diagnosis and Tumor Therapy
title_fullStr Recent Development of Rhenium-Based Materials in the Application of Diagnosis and Tumor Therapy
title_full_unstemmed Recent Development of Rhenium-Based Materials in the Application of Diagnosis and Tumor Therapy
title_short Recent Development of Rhenium-Based Materials in the Application of Diagnosis and Tumor Therapy
title_sort recent development of rhenium-based materials in the application of diagnosis and tumor therapy
topic Review
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10051626/
https://www.ncbi.nlm.nih.gov/pubmed/36985704
http://dx.doi.org/10.3390/molecules28062733
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