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Sleep and Chronobiology as a Key to Understand Cluster Headache
The cluster headache is a primary headache characterized by attacks of unilateral pain associated with ipsilateral cranial autonomic features. These attacks recur in clusters during the years alternating with periods of complete remission, and their onset is often during the night. This annual and n...
Autores principales: | , , , , , , , , , , , |
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Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
MDPI
2023
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Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10051701/ https://www.ncbi.nlm.nih.gov/pubmed/36976672 http://dx.doi.org/10.3390/neurolint15010029 |
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author | Pilati, Laura Torrente, Angelo Alonge, Paolo Vassallo, Lavinia Maccora, Simona Gagliardo, Andrea Pignolo, Antonia Iacono, Salvatore Ferlisi, Salvatore Di Stefano, Vincenzo Camarda, Cecilia Brighina, Filippo |
author_facet | Pilati, Laura Torrente, Angelo Alonge, Paolo Vassallo, Lavinia Maccora, Simona Gagliardo, Andrea Pignolo, Antonia Iacono, Salvatore Ferlisi, Salvatore Di Stefano, Vincenzo Camarda, Cecilia Brighina, Filippo |
author_sort | Pilati, Laura |
collection | PubMed |
description | The cluster headache is a primary headache characterized by attacks of unilateral pain associated with ipsilateral cranial autonomic features. These attacks recur in clusters during the years alternating with periods of complete remission, and their onset is often during the night. This annual and nocturnal periodicity hides a strong and mysterious link among CH, sleep, chronobiology and circadian rhythm. Behind this relationship, there may be the influence of genetic components or of anatomical structures such as the hypothalamus, which are both involved in regulating the biological clock and contributing even to the periodicity of cluster headaches. The bidirectional relationship manifests itself also with the presence of sleep disturbances in patients affected by cluster headaches. What if the key to studying the physiopathology of such disease could rely on the mechanisms of chronobiology? The purpose of this review is to analyze this link in order to interpret the pathophysiology of cluster headaches and the possible therapeutic implications. |
format | Online Article Text |
id | pubmed-10051701 |
institution | National Center for Biotechnology Information |
language | English |
publishDate | 2023 |
publisher | MDPI |
record_format | MEDLINE/PubMed |
spelling | pubmed-100517012023-03-30 Sleep and Chronobiology as a Key to Understand Cluster Headache Pilati, Laura Torrente, Angelo Alonge, Paolo Vassallo, Lavinia Maccora, Simona Gagliardo, Andrea Pignolo, Antonia Iacono, Salvatore Ferlisi, Salvatore Di Stefano, Vincenzo Camarda, Cecilia Brighina, Filippo Neurol Int Review The cluster headache is a primary headache characterized by attacks of unilateral pain associated with ipsilateral cranial autonomic features. These attacks recur in clusters during the years alternating with periods of complete remission, and their onset is often during the night. This annual and nocturnal periodicity hides a strong and mysterious link among CH, sleep, chronobiology and circadian rhythm. Behind this relationship, there may be the influence of genetic components or of anatomical structures such as the hypothalamus, which are both involved in regulating the biological clock and contributing even to the periodicity of cluster headaches. The bidirectional relationship manifests itself also with the presence of sleep disturbances in patients affected by cluster headaches. What if the key to studying the physiopathology of such disease could rely on the mechanisms of chronobiology? The purpose of this review is to analyze this link in order to interpret the pathophysiology of cluster headaches and the possible therapeutic implications. MDPI 2023-03-15 /pmc/articles/PMC10051701/ /pubmed/36976672 http://dx.doi.org/10.3390/neurolint15010029 Text en © 2023 by the authors. https://creativecommons.org/licenses/by/4.0/Licensee MDPI, Basel, Switzerland. This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution (CC BY) license (https://creativecommons.org/licenses/by/4.0/). |
spellingShingle | Review Pilati, Laura Torrente, Angelo Alonge, Paolo Vassallo, Lavinia Maccora, Simona Gagliardo, Andrea Pignolo, Antonia Iacono, Salvatore Ferlisi, Salvatore Di Stefano, Vincenzo Camarda, Cecilia Brighina, Filippo Sleep and Chronobiology as a Key to Understand Cluster Headache |
title | Sleep and Chronobiology as a Key to Understand Cluster Headache |
title_full | Sleep and Chronobiology as a Key to Understand Cluster Headache |
title_fullStr | Sleep and Chronobiology as a Key to Understand Cluster Headache |
title_full_unstemmed | Sleep and Chronobiology as a Key to Understand Cluster Headache |
title_short | Sleep and Chronobiology as a Key to Understand Cluster Headache |
title_sort | sleep and chronobiology as a key to understand cluster headache |
topic | Review |
url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10051701/ https://www.ncbi.nlm.nih.gov/pubmed/36976672 http://dx.doi.org/10.3390/neurolint15010029 |
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