Cytochalasans from the Endophytic Fungus Aspergillus sp. LE2: Their Structures, Antibacterial and NO Production Inhibitory Activities

Six new cytochalasans—namely, aspergicytochalasins A–F (1–6)—together with five known analogs were isolated and characterized from the endophytic fungus Aspergillus sp. from the medicinal plant Lonicera japonica. The structures of the new compounds were established by NMR and MS methods as well as s...

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Autores principales: Li, Yong-Chao, Yang, Jing, Zhao, Yuan-Zeng, Ma, Qin-Di, Liu, Ben-Guo, Sun, Jun-Liang
Formato: Online Artículo Texto
Lenguaje:English
Publicado: MDPI 2023
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10051723/
https://www.ncbi.nlm.nih.gov/pubmed/36983542
http://dx.doi.org/10.3390/jof9030374
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author Li, Yong-Chao
Yang, Jing
Zhao, Yuan-Zeng
Ma, Qin-Di
Liu, Ben-Guo
Sun, Jun-Liang
author_facet Li, Yong-Chao
Yang, Jing
Zhao, Yuan-Zeng
Ma, Qin-Di
Liu, Ben-Guo
Sun, Jun-Liang
author_sort Li, Yong-Chao
collection PubMed
description Six new cytochalasans—namely, aspergicytochalasins A–F (1–6)—together with five known analogs were isolated and characterized from the endophytic fungus Aspergillus sp. from the medicinal plant Lonicera japonica. The structures of the new compounds were established by NMR and MS methods as well as single crystal X-ray diffractions. Compounds 3 and 4 showed weak antibacterial activities to Staphylococcus aureus, with MIC values of 128 and 64 μg/mL, respectively. Compounds 1, 3, 5 and 6 showed inhibitory activities on NO production, with IC(50) values less than 40 μM.
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spelling pubmed-100517232023-03-30 Cytochalasans from the Endophytic Fungus Aspergillus sp. LE2: Their Structures, Antibacterial and NO Production Inhibitory Activities Li, Yong-Chao Yang, Jing Zhao, Yuan-Zeng Ma, Qin-Di Liu, Ben-Guo Sun, Jun-Liang J Fungi (Basel) Article Six new cytochalasans—namely, aspergicytochalasins A–F (1–6)—together with five known analogs were isolated and characterized from the endophytic fungus Aspergillus sp. from the medicinal plant Lonicera japonica. The structures of the new compounds were established by NMR and MS methods as well as single crystal X-ray diffractions. Compounds 3 and 4 showed weak antibacterial activities to Staphylococcus aureus, with MIC values of 128 and 64 μg/mL, respectively. Compounds 1, 3, 5 and 6 showed inhibitory activities on NO production, with IC(50) values less than 40 μM. MDPI 2023-03-19 /pmc/articles/PMC10051723/ /pubmed/36983542 http://dx.doi.org/10.3390/jof9030374 Text en © 2023 by the authors. https://creativecommons.org/licenses/by/4.0/Licensee MDPI, Basel, Switzerland. This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution (CC BY) license (https://creativecommons.org/licenses/by/4.0/).
spellingShingle Article
Li, Yong-Chao
Yang, Jing
Zhao, Yuan-Zeng
Ma, Qin-Di
Liu, Ben-Guo
Sun, Jun-Liang
Cytochalasans from the Endophytic Fungus Aspergillus sp. LE2: Their Structures, Antibacterial and NO Production Inhibitory Activities
title Cytochalasans from the Endophytic Fungus Aspergillus sp. LE2: Their Structures, Antibacterial and NO Production Inhibitory Activities
title_full Cytochalasans from the Endophytic Fungus Aspergillus sp. LE2: Their Structures, Antibacterial and NO Production Inhibitory Activities
title_fullStr Cytochalasans from the Endophytic Fungus Aspergillus sp. LE2: Their Structures, Antibacterial and NO Production Inhibitory Activities
title_full_unstemmed Cytochalasans from the Endophytic Fungus Aspergillus sp. LE2: Their Structures, Antibacterial and NO Production Inhibitory Activities
title_short Cytochalasans from the Endophytic Fungus Aspergillus sp. LE2: Their Structures, Antibacterial and NO Production Inhibitory Activities
title_sort cytochalasans from the endophytic fungus aspergillus sp. le2: their structures, antibacterial and no production inhibitory activities
topic Article
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10051723/
https://www.ncbi.nlm.nih.gov/pubmed/36983542
http://dx.doi.org/10.3390/jof9030374
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