Combined Inhibition of Hedgehog and HDAC6: In Vitro and In Vivo Studies Reveal a New Role for Lysosomal Stress in Reducing Glioblastoma Cell Viability

Glioblastoma multiforme (GBM) is the most common and malignant brain tumor in adults. The invasiveness and the rapid progression that characterize GBM negatively impact patients’ survival. Temozolomide (TMZ) is currently considered the first-choice chemotherapeutic agent. Unfortunately, over 50% of...

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Detalles Bibliográficos
Autores principales: Pezzotta, Alex, Brioschi, Loredana, Carbone, Sabrina, Mazzoleni, Beatrice, Bontempi, Vittorio, Monastra, Federica, Mauri, Laura, Marozzi, Anna, Mione, Marina, Pistocchi, Anna, Viani, Paola
Formato: Online Artículo Texto
Lenguaje:English
Publicado: MDPI 2023
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10051748/
https://www.ncbi.nlm.nih.gov/pubmed/36982845
http://dx.doi.org/10.3390/ijms24065771

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