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Modification of the Linker Amino Acid in the Cell-Penetrating Peptide NickFect55 Leads to Enhanced pDNA Transfection for In Vivo Applications
Despite numerous efforts over the last three decades, nucleic acid-based therapeutics still lack delivery platforms in the clinical stage. Cell-penetrating peptides (CPPs) may offer solutions as potential delivery vectors. We have previously shown that designing a “kinked” structure in the peptide b...
Autores principales: | Härk, Heleri H., Porosk, Ly, de Mello, Lucas R., Arukuusk, Piret, da Silva, Emerson R., Kurrikoff, Kaido |
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Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
MDPI
2023
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Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10051810/ https://www.ncbi.nlm.nih.gov/pubmed/36986744 http://dx.doi.org/10.3390/pharmaceutics15030883 |
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