The Role of Histone Modifications in the Pathogenesis of Diabetic Kidney Disease

Diabetic kidney disease (DKD) is the leading cause of chronic kidney disease. The pathogenesis of DKD is multifactorial, with several molecular pathways implicated. Recent data suggest that histone modification plays an important role in the development and progression of DKD. Histone modification a...

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Detalles Bibliográficos
Autores principales: Kourtidou, Christodoula, Tziomalos, Konstantinos
Formato: Online Artículo Texto
Lenguaje:English
Publicado: MDPI 2023
Materias:
Perspective
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10051814/
https://www.ncbi.nlm.nih.gov/pubmed/36983082
http://dx.doi.org/10.3390/ijms24066007
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author Kourtidou, Christodoula
Tziomalos, Konstantinos
author_facet Kourtidou, Christodoula
Tziomalos, Konstantinos
author_sort Kourtidou, Christodoula
collection PubMed
description Diabetic kidney disease (DKD) is the leading cause of chronic kidney disease. The pathogenesis of DKD is multifactorial, with several molecular pathways implicated. Recent data suggest that histone modification plays an important role in the development and progression of DKD. Histone modification appears to induce oxidative stress, inflammation and fibrosis in the diabetic kidney. In the present review, we summarize the current knowledge on the association between histone modification and DKD.
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spelling pubmed-100518142023-03-30 The Role of Histone Modifications in the Pathogenesis of Diabetic Kidney Disease Kourtidou, Christodoula Tziomalos, Konstantinos Int J Mol Sci Perspective Diabetic kidney disease (DKD) is the leading cause of chronic kidney disease. The pathogenesis of DKD is multifactorial, with several molecular pathways implicated. Recent data suggest that histone modification plays an important role in the development and progression of DKD. Histone modification appears to induce oxidative stress, inflammation and fibrosis in the diabetic kidney. In the present review, we summarize the current knowledge on the association between histone modification and DKD. MDPI 2023-03-22 /pmc/articles/PMC10051814/ /pubmed/36983082 http://dx.doi.org/10.3390/ijms24066007 Text en © 2023 by the authors. https://creativecommons.org/licenses/by/4.0/Licensee MDPI, Basel, Switzerland. This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution (CC BY) license (https://creativecommons.org/licenses/by/4.0/).
spellingShingle Perspective
Kourtidou, Christodoula
Tziomalos, Konstantinos
The Role of Histone Modifications in the Pathogenesis of Diabetic Kidney Disease
title The Role of Histone Modifications in the Pathogenesis of Diabetic Kidney Disease
title_full The Role of Histone Modifications in the Pathogenesis of Diabetic Kidney Disease
title_fullStr The Role of Histone Modifications in the Pathogenesis of Diabetic Kidney Disease
title_full_unstemmed The Role of Histone Modifications in the Pathogenesis of Diabetic Kidney Disease
title_short The Role of Histone Modifications in the Pathogenesis of Diabetic Kidney Disease
title_sort role of histone modifications in the pathogenesis of diabetic kidney disease
topic Perspective
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10051814/
https://www.ncbi.nlm.nih.gov/pubmed/36983082
http://dx.doi.org/10.3390/ijms24066007
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