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Recent Advances of Photoactive Near-Infrared Carbon Dots in Cancer Photodynamic Therapy

Photodynamic therapy (PDT) is a treatment that employs exogenously produced reactive oxygen species (ROS) to kill cancer cells. ROS are generated from the interaction of excited-state photosensitizers (PSs) or photosensitizing agents with molecular oxygen. Novel PSs with high ROS generation efficien...

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Detalles Bibliográficos
Autores principales: Song, Jinxing, Gao, Xiaobo, Yang, Mei, Hao, Weiju, Ji, Ding-Kun
Formato: Online Artículo Texto
Lenguaje:English
Publicado: MDPI 2023
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10051950/
https://www.ncbi.nlm.nih.gov/pubmed/36986621
http://dx.doi.org/10.3390/pharmaceutics15030760
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author Song, Jinxing
Gao, Xiaobo
Yang, Mei
Hao, Weiju
Ji, Ding-Kun
author_facet Song, Jinxing
Gao, Xiaobo
Yang, Mei
Hao, Weiju
Ji, Ding-Kun
author_sort Song, Jinxing
collection PubMed
description Photodynamic therapy (PDT) is a treatment that employs exogenously produced reactive oxygen species (ROS) to kill cancer cells. ROS are generated from the interaction of excited-state photosensitizers (PSs) or photosensitizing agents with molecular oxygen. Novel PSs with high ROS generation efficiency is essential and highly required for cancer photodynamic therapy. Carbon dots (CDs), the rising star of carbon-based nanomaterial family, have shown great potential in cancer PDT benefiting from their excellent photoactivity, luminescence properties, low price, and biocompatibility. In recent years, photoactive near-infrared CDs (PNCDs) have attracted increasing interest in this field due to their deep therapeutic tissue penetration, superior imaging performance, excellent photoactivity, and photostability. In this review, we review recent progress in the designs, fabrication, and applications of PNCDs in cancer PDT. We also provide insights of future directions in accelerating the clinical progress of PNCDs.
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spelling pubmed-100519502023-03-30 Recent Advances of Photoactive Near-Infrared Carbon Dots in Cancer Photodynamic Therapy Song, Jinxing Gao, Xiaobo Yang, Mei Hao, Weiju Ji, Ding-Kun Pharmaceutics Review Photodynamic therapy (PDT) is a treatment that employs exogenously produced reactive oxygen species (ROS) to kill cancer cells. ROS are generated from the interaction of excited-state photosensitizers (PSs) or photosensitizing agents with molecular oxygen. Novel PSs with high ROS generation efficiency is essential and highly required for cancer photodynamic therapy. Carbon dots (CDs), the rising star of carbon-based nanomaterial family, have shown great potential in cancer PDT benefiting from their excellent photoactivity, luminescence properties, low price, and biocompatibility. In recent years, photoactive near-infrared CDs (PNCDs) have attracted increasing interest in this field due to their deep therapeutic tissue penetration, superior imaging performance, excellent photoactivity, and photostability. In this review, we review recent progress in the designs, fabrication, and applications of PNCDs in cancer PDT. We also provide insights of future directions in accelerating the clinical progress of PNCDs. MDPI 2023-02-24 /pmc/articles/PMC10051950/ /pubmed/36986621 http://dx.doi.org/10.3390/pharmaceutics15030760 Text en © 2023 by the authors. https://creativecommons.org/licenses/by/4.0/Licensee MDPI, Basel, Switzerland. This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution (CC BY) license (https://creativecommons.org/licenses/by/4.0/).
spellingShingle Review
Song, Jinxing
Gao, Xiaobo
Yang, Mei
Hao, Weiju
Ji, Ding-Kun
Recent Advances of Photoactive Near-Infrared Carbon Dots in Cancer Photodynamic Therapy
title Recent Advances of Photoactive Near-Infrared Carbon Dots in Cancer Photodynamic Therapy
title_full Recent Advances of Photoactive Near-Infrared Carbon Dots in Cancer Photodynamic Therapy
title_fullStr Recent Advances of Photoactive Near-Infrared Carbon Dots in Cancer Photodynamic Therapy
title_full_unstemmed Recent Advances of Photoactive Near-Infrared Carbon Dots in Cancer Photodynamic Therapy
title_short Recent Advances of Photoactive Near-Infrared Carbon Dots in Cancer Photodynamic Therapy
title_sort recent advances of photoactive near-infrared carbon dots in cancer photodynamic therapy
topic Review
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10051950/
https://www.ncbi.nlm.nih.gov/pubmed/36986621
http://dx.doi.org/10.3390/pharmaceutics15030760
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