Exploring Probenecid Derived 1,3,4-Oxadiazole-Phthalimide Hybrid as α-Amylase Inhibitor: Synthesis, Structural Investigation, and Molecular Modeling

1,3,4-Oxadiazole moiety is a crucial pharmacophore in many biologically active compounds. In a typical synthesis, probenecid was subjected to a sequence of reactions to obtain a 1,3,4-oxadiazole–phthalimide hybrid (PESMP) in high yields. The NMR ((1)H and (13)C) spectroscopic analysis initially conf...

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Detalles Bibliográficos
Autores principales: Khan, Bilal Ahmad, Hamdani, Syeda Shamila, Khalid, Muhammad, Ashfaq, Muhammad, Munawar, Khurram Shahzad, Tahir, Muhammad Nawaz, Braga, Ataualpa A. C., Shawky, Ahmed M., Alqahtani, Alaa M., Abourehab, Mohammed A. S., Gabr, Gamal A., Ibrahim, Mahmoud A. A., Sidhom, Peter A.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: MDPI 2023
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10051969/
https://www.ncbi.nlm.nih.gov/pubmed/36986525
http://dx.doi.org/10.3390/ph16030424

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10051969/
https://www.ncbi.nlm.nih.gov/pubmed/36986525
http://dx.doi.org/10.3390/ph16030424

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