The Potent G-Quadruplex-Binding Compound QN-302 Downregulates S100P Gene Expression in Cells and in an In Vivo Model of Pancreatic Cancer

The naphthalene diimide compound QN-302, designed to bind to G-quadruplex DNA sequences within the promoter regions of cancer-related genes, has high anti-proliferative activity in pancreatic cancer cell lines and anti-tumor activity in several experimental models for the disease. We show here that...

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Detalles Bibliográficos
Autores principales: Ahmed, Ahmed A., Greenhalf, William, Palmer, Daniel H., Williams, Nicole, Worthington, Jenny, Arshad, Tariq, Haider, Shozeb, Alexandrou, Effrosyni, Guneri, Dilek, Waller, Zoe A. E., Neidle, Stephen
Formato: Online Artículo Texto
Lenguaje:English
Publicado: MDPI 2023
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10051992/
https://www.ncbi.nlm.nih.gov/pubmed/36985425
http://dx.doi.org/10.3390/molecules28062452

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