Cargando…
Malnutrition and Insulin Resistance May Interact with Metabolic Syndrome in Prevalent Hemodialysis Patients
Background: We sought to determine the prevalence of metabolic syndrome (Mets) and whether 100 cm(2) of visceral fatty area (VFA) measured by computed tomography (CT) validates the criteria of waist circumference (WC) in hemodialysis (HD) patients. Methods: The study comprised 141 HD patients. Mets...
Autores principales: | , , , , , , , |
---|---|
Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
MDPI
2023
|
Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10051997/ https://www.ncbi.nlm.nih.gov/pubmed/36983240 http://dx.doi.org/10.3390/jcm12062239 |
_version_ | 1785015026418974720 |
---|---|
author | Kobayashi, Shuzo Mochida, Yasuhiro Ishioka, Kunihiro Oka, Machiko Maesato, Kyoko Moriya, Hidekazu Hidaka, Sumi Ohtake, Takayasu |
author_facet | Kobayashi, Shuzo Mochida, Yasuhiro Ishioka, Kunihiro Oka, Machiko Maesato, Kyoko Moriya, Hidekazu Hidaka, Sumi Ohtake, Takayasu |
author_sort | Kobayashi, Shuzo |
collection | PubMed |
description | Background: We sought to determine the prevalence of metabolic syndrome (Mets) and whether 100 cm(2) of visceral fatty area (VFA) measured by computed tomography (CT) validates the criteria of waist circumference (WC) in hemodialysis (HD) patients. Methods: The study comprised 141 HD patients. Mets was defined according to the criteria of Adult Treatment Panel III (ATP III) and the modified criteria of National Cholesterol Education Program (NCEP) that defines abdominal obesity as a WC of >=85 cm in men and >=90 cm in women. Results: The prevalence of Mets was 31.9% in men and 13.6% in women. However, the prevalence of patients with a body mass index over 25 in all HD patients was only 11.2%. The visceral fatty area (VFA) measured by CT showed a strong positive correlation with WC. The patients with Mets, comparing with those without Mets, have significantly shorter duration of HD, higher high-sensitive C-reactive protein, and higher Homeostatic Model Assessment for Insulin Resistance (HOMA-IR). In the patients with Mets, there was a significant negative correlation between HOMA-IR and serum albumin levels. Multivariate logistic regression analysis showed that HOMA-IR and short duration of HD were chosen as independent risk factors for Mets. Conclusions: Mets is more prevalent in HD patients. In Japanese HD patients, 100 cm(2) of VFA corresponded to a WC of 85 cm in men and 90 cm in women, thus confirming the validity of the modified criteria. HOMA-IR and serum albumin were significantly correlated in HD patients with Mets. |
format | Online Article Text |
id | pubmed-10051997 |
institution | National Center for Biotechnology Information |
language | English |
publishDate | 2023 |
publisher | MDPI |
record_format | MEDLINE/PubMed |
spelling | pubmed-100519972023-03-30 Malnutrition and Insulin Resistance May Interact with Metabolic Syndrome in Prevalent Hemodialysis Patients Kobayashi, Shuzo Mochida, Yasuhiro Ishioka, Kunihiro Oka, Machiko Maesato, Kyoko Moriya, Hidekazu Hidaka, Sumi Ohtake, Takayasu J Clin Med Article Background: We sought to determine the prevalence of metabolic syndrome (Mets) and whether 100 cm(2) of visceral fatty area (VFA) measured by computed tomography (CT) validates the criteria of waist circumference (WC) in hemodialysis (HD) patients. Methods: The study comprised 141 HD patients. Mets was defined according to the criteria of Adult Treatment Panel III (ATP III) and the modified criteria of National Cholesterol Education Program (NCEP) that defines abdominal obesity as a WC of >=85 cm in men and >=90 cm in women. Results: The prevalence of Mets was 31.9% in men and 13.6% in women. However, the prevalence of patients with a body mass index over 25 in all HD patients was only 11.2%. The visceral fatty area (VFA) measured by CT showed a strong positive correlation with WC. The patients with Mets, comparing with those without Mets, have significantly shorter duration of HD, higher high-sensitive C-reactive protein, and higher Homeostatic Model Assessment for Insulin Resistance (HOMA-IR). In the patients with Mets, there was a significant negative correlation between HOMA-IR and serum albumin levels. Multivariate logistic regression analysis showed that HOMA-IR and short duration of HD were chosen as independent risk factors for Mets. Conclusions: Mets is more prevalent in HD patients. In Japanese HD patients, 100 cm(2) of VFA corresponded to a WC of 85 cm in men and 90 cm in women, thus confirming the validity of the modified criteria. HOMA-IR and serum albumin were significantly correlated in HD patients with Mets. MDPI 2023-03-14 /pmc/articles/PMC10051997/ /pubmed/36983240 http://dx.doi.org/10.3390/jcm12062239 Text en © 2023 by the authors. https://creativecommons.org/licenses/by/4.0/Licensee MDPI, Basel, Switzerland. This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution (CC BY) license (https://creativecommons.org/licenses/by/4.0/). |
spellingShingle | Article Kobayashi, Shuzo Mochida, Yasuhiro Ishioka, Kunihiro Oka, Machiko Maesato, Kyoko Moriya, Hidekazu Hidaka, Sumi Ohtake, Takayasu Malnutrition and Insulin Resistance May Interact with Metabolic Syndrome in Prevalent Hemodialysis Patients |
title | Malnutrition and Insulin Resistance May Interact with Metabolic Syndrome in Prevalent Hemodialysis Patients |
title_full | Malnutrition and Insulin Resistance May Interact with Metabolic Syndrome in Prevalent Hemodialysis Patients |
title_fullStr | Malnutrition and Insulin Resistance May Interact with Metabolic Syndrome in Prevalent Hemodialysis Patients |
title_full_unstemmed | Malnutrition and Insulin Resistance May Interact with Metabolic Syndrome in Prevalent Hemodialysis Patients |
title_short | Malnutrition and Insulin Resistance May Interact with Metabolic Syndrome in Prevalent Hemodialysis Patients |
title_sort | malnutrition and insulin resistance may interact with metabolic syndrome in prevalent hemodialysis patients |
topic | Article |
url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10051997/ https://www.ncbi.nlm.nih.gov/pubmed/36983240 http://dx.doi.org/10.3390/jcm12062239 |
work_keys_str_mv | AT kobayashishuzo malnutritionandinsulinresistancemayinteractwithmetabolicsyndromeinprevalenthemodialysispatients AT mochidayasuhiro malnutritionandinsulinresistancemayinteractwithmetabolicsyndromeinprevalenthemodialysispatients AT ishiokakunihiro malnutritionandinsulinresistancemayinteractwithmetabolicsyndromeinprevalenthemodialysispatients AT okamachiko malnutritionandinsulinresistancemayinteractwithmetabolicsyndromeinprevalenthemodialysispatients AT maesatokyoko malnutritionandinsulinresistancemayinteractwithmetabolicsyndromeinprevalenthemodialysispatients AT moriyahidekazu malnutritionandinsulinresistancemayinteractwithmetabolicsyndromeinprevalenthemodialysispatients AT hidakasumi malnutritionandinsulinresistancemayinteractwithmetabolicsyndromeinprevalenthemodialysispatients AT ohtaketakayasu malnutritionandinsulinresistancemayinteractwithmetabolicsyndromeinprevalenthemodialysispatients |