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Decoding the Conformational Selective Mechanism of FGFR Isoforms: A Comparative Molecular Dynamics Simulation

Fibroblast growth factor receptors (FGFRs) play critical roles in the regulation of cell growth, differentiation, and proliferation. Specifically, FGFR2 gene amplification has been implicated in gastric and breast cancer. Pan-FGFR inhibitors often cause large toxic side effects, and the highly conse...

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Detalles Bibliográficos
Autores principales:	Zhang, Mingyang, Yasen, Miersalijiang, Lu, Shaoyong, Ma, De-Ning, Chai, Zongtao
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	MDPI 2023
Materias:	Article
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10052029/ https://www.ncbi.nlm.nih.gov/pubmed/36985681 http://dx.doi.org/10.3390/molecules28062709

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