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COVID-19 Is a Confounder of Increased Candida Airway Colonisation

An increased incidence of invasive fungal infection was reported in SARS-CoV-2-infected patients hospitalised in the intensive care unit. However, the impact of COVID-19 on Candida airway colonisation has not yet been assessed. This study aimed to test the impact of several factors on Candida airway...

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Autores principales: Froidefond, Margaux, Sevestre, Jacques, Chaudet, Hervé, Ranque, Stéphane
Formato: Online Artículo Texto
Lenguaje:English
Publicado: MDPI 2023
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10052038/
https://www.ncbi.nlm.nih.gov/pubmed/36986385
http://dx.doi.org/10.3390/pathogens12030463
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author Froidefond, Margaux
Sevestre, Jacques
Chaudet, Hervé
Ranque, Stéphane
author_facet Froidefond, Margaux
Sevestre, Jacques
Chaudet, Hervé
Ranque, Stéphane
author_sort Froidefond, Margaux
collection PubMed
description An increased incidence of invasive fungal infection was reported in SARS-CoV-2-infected patients hospitalised in the intensive care unit. However, the impact of COVID-19 on Candida airway colonisation has not yet been assessed. This study aimed to test the impact of several factors on Candida airway colonisation, including SARS-CoV-2 infection. We conducted a two-pronged monocentric retrospective study. First, we analysed the prevalence of positive yeast culture in respiratory samples obtained from 23 departments of the University Hospital of Marseille between 1 January 2018 and 31 March 2022. We then conducted a case-control study, comparing patients with documented Candida airway colonisation to two control groups. We observed an increase in the prevalence of yeast isolation over the study period. The case-control study included 300 patients. In the multivariate logistic regression, diabetes, mechanical ventilation, length of stay in the hospital, invasive fungal disease, and the use of antibacterials were independently associated with Candida airway colonisation. The association of SARS-CoV-2 infection with an increased risk of Candida airway colonisation is likely to be a consequence of confounding factors. Nevertheless, we found the length of stay in the hospital, mechanical ventilation, diabetes, and the use of antibacterials to be statistically significant independent risk factors of Candida airway colonisation.
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spelling pubmed-100520382023-03-30 COVID-19 Is a Confounder of Increased Candida Airway Colonisation Froidefond, Margaux Sevestre, Jacques Chaudet, Hervé Ranque, Stéphane Pathogens Article An increased incidence of invasive fungal infection was reported in SARS-CoV-2-infected patients hospitalised in the intensive care unit. However, the impact of COVID-19 on Candida airway colonisation has not yet been assessed. This study aimed to test the impact of several factors on Candida airway colonisation, including SARS-CoV-2 infection. We conducted a two-pronged monocentric retrospective study. First, we analysed the prevalence of positive yeast culture in respiratory samples obtained from 23 departments of the University Hospital of Marseille between 1 January 2018 and 31 March 2022. We then conducted a case-control study, comparing patients with documented Candida airway colonisation to two control groups. We observed an increase in the prevalence of yeast isolation over the study period. The case-control study included 300 patients. In the multivariate logistic regression, diabetes, mechanical ventilation, length of stay in the hospital, invasive fungal disease, and the use of antibacterials were independently associated with Candida airway colonisation. The association of SARS-CoV-2 infection with an increased risk of Candida airway colonisation is likely to be a consequence of confounding factors. Nevertheless, we found the length of stay in the hospital, mechanical ventilation, diabetes, and the use of antibacterials to be statistically significant independent risk factors of Candida airway colonisation. MDPI 2023-03-15 /pmc/articles/PMC10052038/ /pubmed/36986385 http://dx.doi.org/10.3390/pathogens12030463 Text en © 2023 by the authors. https://creativecommons.org/licenses/by/4.0/Licensee MDPI, Basel, Switzerland. This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution (CC BY) license (https://creativecommons.org/licenses/by/4.0/).
spellingShingle Article
Froidefond, Margaux
Sevestre, Jacques
Chaudet, Hervé
Ranque, Stéphane
COVID-19 Is a Confounder of Increased Candida Airway Colonisation
title COVID-19 Is a Confounder of Increased Candida Airway Colonisation
title_full COVID-19 Is a Confounder of Increased Candida Airway Colonisation
title_fullStr COVID-19 Is a Confounder of Increased Candida Airway Colonisation
title_full_unstemmed COVID-19 Is a Confounder of Increased Candida Airway Colonisation
title_short COVID-19 Is a Confounder of Increased Candida Airway Colonisation
title_sort covid-19 is a confounder of increased candida airway colonisation
topic Article
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10052038/
https://www.ncbi.nlm.nih.gov/pubmed/36986385
http://dx.doi.org/10.3390/pathogens12030463
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