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Novel Approach for the Approximation of Vitamin D(3) Pharmacokinetics from In Vivo Absorption Studies

The changing environment and modified lifestyles have meant that many vitamins and minerals are deficient in a significant portion of the human population. Therefore, supplementation is a viable nutritional approach, which helps to maintain health and well-being. The supplementation efficiency of a...

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Autores principales: Żurek, Grzegorz, Przybyło, Magdalena, Witkiewicz, Wojciech, Langner, Marek
Formato: Online Artículo Texto
Lenguaje:English
Publicado: MDPI 2023
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10052077/
https://www.ncbi.nlm.nih.gov/pubmed/36986644
http://dx.doi.org/10.3390/pharmaceutics15030783
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author Żurek, Grzegorz
Przybyło, Magdalena
Witkiewicz, Wojciech
Langner, Marek
author_facet Żurek, Grzegorz
Przybyło, Magdalena
Witkiewicz, Wojciech
Langner, Marek
author_sort Żurek, Grzegorz
collection PubMed
description The changing environment and modified lifestyles have meant that many vitamins and minerals are deficient in a significant portion of the human population. Therefore, supplementation is a viable nutritional approach, which helps to maintain health and well-being. The supplementation efficiency of a highly hydrophobic compound such as cholecalciferol (logP > 7) depends predominantly on the formulation. To overcome difficulties associated with the evaluation of pharmacokinetics of cholecalciferol, a method based on the short time absorption data in the clinical study and physiologically based mathematical modeling is proposed. The method was used to compare pharmacokinetics of liposomal and oily formulations of vitamin D(3). The liposomal formulation was more effective in elevating calcidiol concentration in serum. The determined AUC value for liposomal vitamin D(3) formulation was four times bigger than that for the oily formulation.
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spelling pubmed-100520772023-03-30 Novel Approach for the Approximation of Vitamin D(3) Pharmacokinetics from In Vivo Absorption Studies Żurek, Grzegorz Przybyło, Magdalena Witkiewicz, Wojciech Langner, Marek Pharmaceutics Article The changing environment and modified lifestyles have meant that many vitamins and minerals are deficient in a significant portion of the human population. Therefore, supplementation is a viable nutritional approach, which helps to maintain health and well-being. The supplementation efficiency of a highly hydrophobic compound such as cholecalciferol (logP > 7) depends predominantly on the formulation. To overcome difficulties associated with the evaluation of pharmacokinetics of cholecalciferol, a method based on the short time absorption data in the clinical study and physiologically based mathematical modeling is proposed. The method was used to compare pharmacokinetics of liposomal and oily formulations of vitamin D(3). The liposomal formulation was more effective in elevating calcidiol concentration in serum. The determined AUC value for liposomal vitamin D(3) formulation was four times bigger than that for the oily formulation. MDPI 2023-02-27 /pmc/articles/PMC10052077/ /pubmed/36986644 http://dx.doi.org/10.3390/pharmaceutics15030783 Text en © 2023 by the authors. https://creativecommons.org/licenses/by/4.0/Licensee MDPI, Basel, Switzerland. This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution (CC BY) license (https://creativecommons.org/licenses/by/4.0/).
spellingShingle Article
Żurek, Grzegorz
Przybyło, Magdalena
Witkiewicz, Wojciech
Langner, Marek
Novel Approach for the Approximation of Vitamin D(3) Pharmacokinetics from In Vivo Absorption Studies
title Novel Approach for the Approximation of Vitamin D(3) Pharmacokinetics from In Vivo Absorption Studies
title_full Novel Approach for the Approximation of Vitamin D(3) Pharmacokinetics from In Vivo Absorption Studies
title_fullStr Novel Approach for the Approximation of Vitamin D(3) Pharmacokinetics from In Vivo Absorption Studies
title_full_unstemmed Novel Approach for the Approximation of Vitamin D(3) Pharmacokinetics from In Vivo Absorption Studies
title_short Novel Approach for the Approximation of Vitamin D(3) Pharmacokinetics from In Vivo Absorption Studies
title_sort novel approach for the approximation of vitamin d(3) pharmacokinetics from in vivo absorption studies
topic Article
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10052077/
https://www.ncbi.nlm.nih.gov/pubmed/36986644
http://dx.doi.org/10.3390/pharmaceutics15030783
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