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Depressive-like Behavior Is Accompanied by Prefrontal Cortical Innate Immune Fatigue and Dendritic Spine Losses after HIV-1 Tat and Morphine Exposure

Opioid use disorder (OUD) and HIV are comorbid epidemics that can increase depression. HIV and the viral protein Tat can directly induce neuronal injury within reward and emotionality brain circuitry, including the prefrontal cortex (PFC). Such damage involves both excitotoxic mechanisms and more in...

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Detalles Bibliográficos
Autores principales:	Nass, Sara R., Hahn, Yun K., Ohene-Nyako, Michael, McLane, Virginia D., Damaj, M. Imad, Thacker, Leroy R., Knapp, Pamela E., Hauser, Kurt F.
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	MDPI 2023
Materias:	Article
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10052300/ https://www.ncbi.nlm.nih.gov/pubmed/36992299 http://dx.doi.org/10.3390/v15030590

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