Reduction in the number of neutrophils in the broncho-alveolar aspirate is associated with worse prognosis in elderly patients with severe COVID-19

The blood levels of neutrophils are associated with the severity of COVID -19. However, their role in the pulmonary environment during COVID -19 severity is not clear. Here, we found a decrease in the neutrophil count in BAL (bronchoalveolar lavage) in non-survivors and in older patients (> 60 ye...

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Autores principales: Arifa, Raquel Duque Nascimento, Gonçalves-Pereira, Marcela Helena, Santiago, Luciana, Ravetti, Cecilia Gómez, Vassallo, Paula Frizera, de Fátima Souza Oliveira, Fernanda, de Paula Sabino, Adriano, Teixeira, Mauro Martins, Nobre, Vandack, da Costa Santiago, Helton, Souza, Daniele G.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Springer International Publishing 2023
Materias:
Original Research Paper
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10052312/
https://www.ncbi.nlm.nih.gov/pubmed/36988640
http://dx.doi.org/10.1007/s00011-023-01726-y
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author Arifa, Raquel Duque Nascimento
Gonçalves-Pereira, Marcela Helena
Santiago, Luciana
Ravetti, Cecilia Gómez
Vassallo, Paula Frizera
de Fátima Souza Oliveira, Fernanda
de Paula Sabino, Adriano
Teixeira, Mauro Martins
Nobre, Vandack
da Costa Santiago, Helton
Souza, Daniele G.
author_facet Arifa, Raquel Duque Nascimento
Gonçalves-Pereira, Marcela Helena
Santiago, Luciana
Ravetti, Cecilia Gómez
Vassallo, Paula Frizera
de Fátima Souza Oliveira, Fernanda
de Paula Sabino, Adriano
Teixeira, Mauro Martins
Nobre, Vandack
da Costa Santiago, Helton
Souza, Daniele G.
author_sort Arifa, Raquel Duque Nascimento
collection PubMed
description The blood levels of neutrophils are associated with the severity of COVID -19. However, their role in the pulmonary environment during COVID -19 severity is not clear. Here, we found a decrease in the neutrophil count in BAL (bronchoalveolar lavage) in non-survivors and in older patients (> 60 years). In addition, we have shown that older patients have higher serum concentration of CXCL8 and increased IL-10 expression by neutrophils.
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spelling pubmed-100523122023-03-29 Reduction in the number of neutrophils in the broncho-alveolar aspirate is associated with worse prognosis in elderly patients with severe COVID-19 Arifa, Raquel Duque Nascimento Gonçalves-Pereira, Marcela Helena Santiago, Luciana Ravetti, Cecilia Gómez Vassallo, Paula Frizera de Fátima Souza Oliveira, Fernanda de Paula Sabino, Adriano Teixeira, Mauro Martins Nobre, Vandack da Costa Santiago, Helton Souza, Daniele G. Inflamm Res Original Research Paper The blood levels of neutrophils are associated with the severity of COVID -19. However, their role in the pulmonary environment during COVID -19 severity is not clear. Here, we found a decrease in the neutrophil count in BAL (bronchoalveolar lavage) in non-survivors and in older patients (> 60 years). In addition, we have shown that older patients have higher serum concentration of CXCL8 and increased IL-10 expression by neutrophils. Springer International Publishing 2023-03-29 2023 /pmc/articles/PMC10052312/ /pubmed/36988640 http://dx.doi.org/10.1007/s00011-023-01726-y Text en © The Author(s), under exclusive licence to Springer Nature Switzerland AG 2023, Springer Nature or its licensor (e.g. a society or other partner) holds exclusive rights to this article under a publishing agreement with the author(s) or other rightsholder(s); author self-archiving of the accepted manuscript version of this article is solely governed by the terms of such publishing agreement and applicable law. This article is made available via the PMC Open Access Subset for unrestricted research re-use and secondary analysis in any form or by any means with acknowledgement of the original source. These permissions are granted for the duration of the World Health Organization (WHO) declaration of COVID-19 as a global pandemic.
spellingShingle Original Research Paper
Arifa, Raquel Duque Nascimento
Gonçalves-Pereira, Marcela Helena
Santiago, Luciana
Ravetti, Cecilia Gómez
Vassallo, Paula Frizera
de Fátima Souza Oliveira, Fernanda
de Paula Sabino, Adriano
Teixeira, Mauro Martins
Nobre, Vandack
da Costa Santiago, Helton
Souza, Daniele G.
Reduction in the number of neutrophils in the broncho-alveolar aspirate is associated with worse prognosis in elderly patients with severe COVID-19
title Reduction in the number of neutrophils in the broncho-alveolar aspirate is associated with worse prognosis in elderly patients with severe COVID-19
title_full Reduction in the number of neutrophils in the broncho-alveolar aspirate is associated with worse prognosis in elderly patients with severe COVID-19
title_fullStr Reduction in the number of neutrophils in the broncho-alveolar aspirate is associated with worse prognosis in elderly patients with severe COVID-19
title_full_unstemmed Reduction in the number of neutrophils in the broncho-alveolar aspirate is associated with worse prognosis in elderly patients with severe COVID-19
title_short Reduction in the number of neutrophils in the broncho-alveolar aspirate is associated with worse prognosis in elderly patients with severe COVID-19
title_sort reduction in the number of neutrophils in the broncho-alveolar aspirate is associated with worse prognosis in elderly patients with severe covid-19
topic Original Research Paper
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10052312/
https://www.ncbi.nlm.nih.gov/pubmed/36988640
http://dx.doi.org/10.1007/s00011-023-01726-y
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