Cargando…
Pancreatitis and Pancreatic Cancer Risk
Purpose: The present retrospective study aimed to explore the relationship between pancreatitis and pancreatic cancer in the population cohort of the UK Biobank (UKB) (https://www.ukbiobank.ac.uk). Methods: From the 500 thousand population cohort of UKB, according to the age and gender of patients w...
Autores principales: | , , , , , , |
---|---|
Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
SAGE Publications
2023
|
Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10052482/ https://www.ncbi.nlm.nih.gov/pubmed/36972517 http://dx.doi.org/10.1177/15330338231164875 |
_version_ | 1785015171922526208 |
---|---|
author | Ma, Dong-Mei Dong, Xiao-Wu Han, Xiao Ling, Zhi Lu, Guo-Tao Sun, Yun-Yun Yin, Xu-Dong |
author_facet | Ma, Dong-Mei Dong, Xiao-Wu Han, Xiao Ling, Zhi Lu, Guo-Tao Sun, Yun-Yun Yin, Xu-Dong |
author_sort | Ma, Dong-Mei |
collection | PubMed |
description | Purpose: The present retrospective study aimed to explore the relationship between pancreatitis and pancreatic cancer in the population cohort of the UK Biobank (UKB) (https://www.ukbiobank.ac.uk). Methods: From the 500 thousand population cohort of UKB, according to the age and gender of patients with pancreatic cancer 1:10, matching the control without pancreatic cancer, the binary Logistic regression model was used to analyze the relationship between pancreatitis and pancreatic cancer, and subgroup analyses were used to identify potential effect modifiers. Results: A total of 1538 patients with pancreatic cancer were compared with 15 380 controls. In the fully adjusted model, patients with pancreatitis had a significantly increased risk of pancreatic cancer compared with no pancreatitis. The risk of pancreatitis and pancreatic cancer increased with the age of pancreatitis, and the risk of pancreatic cancer was highest in the 61 to 70 age group. In addition, in the first 3 years of acute pancreatitis, the risk of pancreatic cancer increased significantly with the increase in the duration of the disease (odds ratio [OR] 29.13, 95% confidence interval [CI]: 16.34-51.93), after 3 years, the trend of increase decreased. After more than 10 years, there was no significant correlation between the risk of acute pancreatitis and pancreatic cancer. However, patients with chronic pancreatitis were significantly associated with an increased risk of pancreatic cancer only in the first 3 years (OR 28.14, 95% CI: 14.86-53.31). Conclusion: Pancreatitis may associate with an increased risk of pancreatic cancer. The older the age of pancreatitis, the higher the risk of pancreatic cancer. The risk of pancreatic cancer increases significantly in the first 3 years of the course of pancreatitis. This may provide an alternative strategy for the early identification of individuals at high risk of pancreatic cancer. |
format | Online Article Text |
id | pubmed-10052482 |
institution | National Center for Biotechnology Information |
language | English |
publishDate | 2023 |
publisher | SAGE Publications |
record_format | MEDLINE/PubMed |
spelling | pubmed-100524822023-03-30 Pancreatitis and Pancreatic Cancer Risk Ma, Dong-Mei Dong, Xiao-Wu Han, Xiao Ling, Zhi Lu, Guo-Tao Sun, Yun-Yun Yin, Xu-Dong Technol Cancer Res Treat Original Article Purpose: The present retrospective study aimed to explore the relationship between pancreatitis and pancreatic cancer in the population cohort of the UK Biobank (UKB) (https://www.ukbiobank.ac.uk). Methods: From the 500 thousand population cohort of UKB, according to the age and gender of patients with pancreatic cancer 1:10, matching the control without pancreatic cancer, the binary Logistic regression model was used to analyze the relationship between pancreatitis and pancreatic cancer, and subgroup analyses were used to identify potential effect modifiers. Results: A total of 1538 patients with pancreatic cancer were compared with 15 380 controls. In the fully adjusted model, patients with pancreatitis had a significantly increased risk of pancreatic cancer compared with no pancreatitis. The risk of pancreatitis and pancreatic cancer increased with the age of pancreatitis, and the risk of pancreatic cancer was highest in the 61 to 70 age group. In addition, in the first 3 years of acute pancreatitis, the risk of pancreatic cancer increased significantly with the increase in the duration of the disease (odds ratio [OR] 29.13, 95% confidence interval [CI]: 16.34-51.93), after 3 years, the trend of increase decreased. After more than 10 years, there was no significant correlation between the risk of acute pancreatitis and pancreatic cancer. However, patients with chronic pancreatitis were significantly associated with an increased risk of pancreatic cancer only in the first 3 years (OR 28.14, 95% CI: 14.86-53.31). Conclusion: Pancreatitis may associate with an increased risk of pancreatic cancer. The older the age of pancreatitis, the higher the risk of pancreatic cancer. The risk of pancreatic cancer increases significantly in the first 3 years of the course of pancreatitis. This may provide an alternative strategy for the early identification of individuals at high risk of pancreatic cancer. SAGE Publications 2023-03-27 /pmc/articles/PMC10052482/ /pubmed/36972517 http://dx.doi.org/10.1177/15330338231164875 Text en © The Author(s) 2023 https://creativecommons.org/licenses/by-nc/4.0/This article is distributed under the terms of the Creative Commons Attribution-NonCommercial 4.0 License (https://creativecommons.org/licenses/by-nc/4.0/) which permits non-commercial use, reproduction and distribution of the work without further permission provided the original work is attributed as specified on the SAGE and Open Access page (https://us.sagepub.com/en-us/nam/open-access-at-sage). |
spellingShingle | Original Article Ma, Dong-Mei Dong, Xiao-Wu Han, Xiao Ling, Zhi Lu, Guo-Tao Sun, Yun-Yun Yin, Xu-Dong Pancreatitis and Pancreatic Cancer Risk |
title | Pancreatitis and Pancreatic Cancer Risk |
title_full | Pancreatitis and Pancreatic Cancer Risk |
title_fullStr | Pancreatitis and Pancreatic Cancer Risk |
title_full_unstemmed | Pancreatitis and Pancreatic Cancer Risk |
title_short | Pancreatitis and Pancreatic Cancer Risk |
title_sort | pancreatitis and pancreatic cancer risk |
topic | Original Article |
url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10052482/ https://www.ncbi.nlm.nih.gov/pubmed/36972517 http://dx.doi.org/10.1177/15330338231164875 |
work_keys_str_mv | AT madongmei pancreatitisandpancreaticcancerrisk AT dongxiaowu pancreatitisandpancreaticcancerrisk AT hanxiao pancreatitisandpancreaticcancerrisk AT lingzhi pancreatitisandpancreaticcancerrisk AT luguotao pancreatitisandpancreaticcancerrisk AT sunyunyun pancreatitisandpancreaticcancerrisk AT yinxudong pancreatitisandpancreaticcancerrisk |