Cargando…

A Paternal Fish Oil Diet Preconception Reduces Lung Inflammation in a Toxicant-Driven Murine Model of New Bronchopulmonary Dysplasia

New bronchopulmonary dysplasia (BPD) is a neonatal disease that is theorized to begin in utero and manifests as reduced alveolarization due to inflammation of the lung. Risk factors for new BPD in human infants include intrauterine growth restriction (IUGR), premature birth (PTB) and formula feeding...

Descripción completa

Detalles Bibliográficos
Autores principales: Rumph, Jelonia T., Stephens, Victoria R., Ameli, Sharareh, Brown, LaKendria K., Rayford, Kayla J., Nde, Pius N., Osteen, Kevin G., Bruner-Tran, Kaylon L.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: MDPI 2023
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10052688/
https://www.ncbi.nlm.nih.gov/pubmed/36976210
http://dx.doi.org/10.3390/md21030161
_version_ 1785015218553749504
author Rumph, Jelonia T.
Stephens, Victoria R.
Ameli, Sharareh
Brown, LaKendria K.
Rayford, Kayla J.
Nde, Pius N.
Osteen, Kevin G.
Bruner-Tran, Kaylon L.
author_facet Rumph, Jelonia T.
Stephens, Victoria R.
Ameli, Sharareh
Brown, LaKendria K.
Rayford, Kayla J.
Nde, Pius N.
Osteen, Kevin G.
Bruner-Tran, Kaylon L.
author_sort Rumph, Jelonia T.
collection PubMed
description New bronchopulmonary dysplasia (BPD) is a neonatal disease that is theorized to begin in utero and manifests as reduced alveolarization due to inflammation of the lung. Risk factors for new BPD in human infants include intrauterine growth restriction (IUGR), premature birth (PTB) and formula feeding. Using a mouse model, our group recently reported that a paternal history of 2,3,7,8-tetrachlorodibenzo-p-dioxin (TCDD) exposure increased his offspring’s risk of IUGR, PTB, and new BPD. Additionally, formula supplementation of these neonates worsened the severity of pulmonary disease. In a separate study, we reported that a paternal preconception fish oil diet prevented TCDD-driven IUGR and PTB. Not surprisingly, eliminating these two major risk factors for new BPD also significantly reduced development of neonatal lung disease. However, this prior study did not examine the potential mechanism for fish oil’s protective effect. Herein, we sought to determine whether a paternal preconception fish oil diet attenuated toxicant-associated lung inflammation, which is an important contributor to the pathogenesis of new BPD. Compared to offspring of standard diet TCDD-exposed males, offspring of TCDD-exposed males provided a fish oil diet prior to conception exhibited a significant reduction in pulmonary expression of multiple pro-inflammatory mediators (Tlr4, Cxcr2, Il-1 alpha). Additionally, neonatal lungs of pups born to fish oil treated fathers exhibited minimal hemorrhaging or edema. Currently, prevention of BPD is largely focused on maternal strategies to improve health (e.g., smoking cessation) or reduce risk of PTB (e.g., progesterone supplementation). Our studies in mice support a role for also targeting paternal factors to improve pregnancy outcomes and child health.
format Online
Article
Text
id pubmed-10052688
institution National Center for Biotechnology Information
language English
publishDate 2023
publisher MDPI
record_format MEDLINE/PubMed
spelling pubmed-100526882023-03-30 A Paternal Fish Oil Diet Preconception Reduces Lung Inflammation in a Toxicant-Driven Murine Model of New Bronchopulmonary Dysplasia Rumph, Jelonia T. Stephens, Victoria R. Ameli, Sharareh Brown, LaKendria K. Rayford, Kayla J. Nde, Pius N. Osteen, Kevin G. Bruner-Tran, Kaylon L. Mar Drugs Article New bronchopulmonary dysplasia (BPD) is a neonatal disease that is theorized to begin in utero and manifests as reduced alveolarization due to inflammation of the lung. Risk factors for new BPD in human infants include intrauterine growth restriction (IUGR), premature birth (PTB) and formula feeding. Using a mouse model, our group recently reported that a paternal history of 2,3,7,8-tetrachlorodibenzo-p-dioxin (TCDD) exposure increased his offspring’s risk of IUGR, PTB, and new BPD. Additionally, formula supplementation of these neonates worsened the severity of pulmonary disease. In a separate study, we reported that a paternal preconception fish oil diet prevented TCDD-driven IUGR and PTB. Not surprisingly, eliminating these two major risk factors for new BPD also significantly reduced development of neonatal lung disease. However, this prior study did not examine the potential mechanism for fish oil’s protective effect. Herein, we sought to determine whether a paternal preconception fish oil diet attenuated toxicant-associated lung inflammation, which is an important contributor to the pathogenesis of new BPD. Compared to offspring of standard diet TCDD-exposed males, offspring of TCDD-exposed males provided a fish oil diet prior to conception exhibited a significant reduction in pulmonary expression of multiple pro-inflammatory mediators (Tlr4, Cxcr2, Il-1 alpha). Additionally, neonatal lungs of pups born to fish oil treated fathers exhibited minimal hemorrhaging or edema. Currently, prevention of BPD is largely focused on maternal strategies to improve health (e.g., smoking cessation) or reduce risk of PTB (e.g., progesterone supplementation). Our studies in mice support a role for also targeting paternal factors to improve pregnancy outcomes and child health. MDPI 2023-02-27 /pmc/articles/PMC10052688/ /pubmed/36976210 http://dx.doi.org/10.3390/md21030161 Text en © 2023 by the authors. https://creativecommons.org/licenses/by/4.0/Licensee MDPI, Basel, Switzerland. This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution (CC BY) license (https://creativecommons.org/licenses/by/4.0/).
spellingShingle Article
Rumph, Jelonia T.
Stephens, Victoria R.
Ameli, Sharareh
Brown, LaKendria K.
Rayford, Kayla J.
Nde, Pius N.
Osteen, Kevin G.
Bruner-Tran, Kaylon L.
A Paternal Fish Oil Diet Preconception Reduces Lung Inflammation in a Toxicant-Driven Murine Model of New Bronchopulmonary Dysplasia
title A Paternal Fish Oil Diet Preconception Reduces Lung Inflammation in a Toxicant-Driven Murine Model of New Bronchopulmonary Dysplasia
title_full A Paternal Fish Oil Diet Preconception Reduces Lung Inflammation in a Toxicant-Driven Murine Model of New Bronchopulmonary Dysplasia
title_fullStr A Paternal Fish Oil Diet Preconception Reduces Lung Inflammation in a Toxicant-Driven Murine Model of New Bronchopulmonary Dysplasia
title_full_unstemmed A Paternal Fish Oil Diet Preconception Reduces Lung Inflammation in a Toxicant-Driven Murine Model of New Bronchopulmonary Dysplasia
title_short A Paternal Fish Oil Diet Preconception Reduces Lung Inflammation in a Toxicant-Driven Murine Model of New Bronchopulmonary Dysplasia
title_sort paternal fish oil diet preconception reduces lung inflammation in a toxicant-driven murine model of new bronchopulmonary dysplasia
topic Article
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10052688/
https://www.ncbi.nlm.nih.gov/pubmed/36976210
http://dx.doi.org/10.3390/md21030161
work_keys_str_mv AT rumphjeloniat apaternalfishoildietpreconceptionreduceslunginflammationinatoxicantdrivenmurinemodelofnewbronchopulmonarydysplasia
AT stephensvictoriar apaternalfishoildietpreconceptionreduceslunginflammationinatoxicantdrivenmurinemodelofnewbronchopulmonarydysplasia
AT amelisharareh apaternalfishoildietpreconceptionreduceslunginflammationinatoxicantdrivenmurinemodelofnewbronchopulmonarydysplasia
AT brownlakendriak apaternalfishoildietpreconceptionreduceslunginflammationinatoxicantdrivenmurinemodelofnewbronchopulmonarydysplasia
AT rayfordkaylaj apaternalfishoildietpreconceptionreduceslunginflammationinatoxicantdrivenmurinemodelofnewbronchopulmonarydysplasia
AT ndepiusn apaternalfishoildietpreconceptionreduceslunginflammationinatoxicantdrivenmurinemodelofnewbronchopulmonarydysplasia
AT osteenkeving apaternalfishoildietpreconceptionreduceslunginflammationinatoxicantdrivenmurinemodelofnewbronchopulmonarydysplasia
AT brunertrankaylonl apaternalfishoildietpreconceptionreduceslunginflammationinatoxicantdrivenmurinemodelofnewbronchopulmonarydysplasia
AT rumphjeloniat paternalfishoildietpreconceptionreduceslunginflammationinatoxicantdrivenmurinemodelofnewbronchopulmonarydysplasia
AT stephensvictoriar paternalfishoildietpreconceptionreduceslunginflammationinatoxicantdrivenmurinemodelofnewbronchopulmonarydysplasia
AT amelisharareh paternalfishoildietpreconceptionreduceslunginflammationinatoxicantdrivenmurinemodelofnewbronchopulmonarydysplasia
AT brownlakendriak paternalfishoildietpreconceptionreduceslunginflammationinatoxicantdrivenmurinemodelofnewbronchopulmonarydysplasia
AT rayfordkaylaj paternalfishoildietpreconceptionreduceslunginflammationinatoxicantdrivenmurinemodelofnewbronchopulmonarydysplasia
AT ndepiusn paternalfishoildietpreconceptionreduceslunginflammationinatoxicantdrivenmurinemodelofnewbronchopulmonarydysplasia
AT osteenkeving paternalfishoildietpreconceptionreduceslunginflammationinatoxicantdrivenmurinemodelofnewbronchopulmonarydysplasia
AT brunertrankaylonl paternalfishoildietpreconceptionreduceslunginflammationinatoxicantdrivenmurinemodelofnewbronchopulmonarydysplasia