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Cardiovascular disease-linked plasma proteins are mainly associated with lung volume
BACKGROUND: Epidemiological studies have shown that impaired lung function is common and associated with increased risk of cardiovascular disease. Increased levels of several inflammatory and cardiovascular disease-related plasma proteins have been associated with impaired lung function. The aim was...
Autores principales: | , , , , , , , , , , , , , , |
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Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
European Respiratory Society
2023
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Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10052712/ https://www.ncbi.nlm.nih.gov/pubmed/37009020 http://dx.doi.org/10.1183/23120541.00321-2022 |
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author | Rydell, Andreas Nerpin, Elisabet Zhou, XingWu Lind, Lars Lindberg, Eva Theorell Haglöw, Jenny Fall, Tove Janson, Christer Lisspers, Karin Elmståhl, Sölve Zaigham, Suneela Melander, Olle Nilsson, Peter M. Ärnlöv, Johan Malinovschi, Andrei |
author_facet | Rydell, Andreas Nerpin, Elisabet Zhou, XingWu Lind, Lars Lindberg, Eva Theorell Haglöw, Jenny Fall, Tove Janson, Christer Lisspers, Karin Elmståhl, Sölve Zaigham, Suneela Melander, Olle Nilsson, Peter M. Ärnlöv, Johan Malinovschi, Andrei |
author_sort | Rydell, Andreas |
collection | PubMed |
description | BACKGROUND: Epidemiological studies have shown that impaired lung function is common and associated with increased risk of cardiovascular disease. Increased levels of several inflammatory and cardiovascular disease-related plasma proteins have been associated with impaired lung function. The aim was to study the association between plasma proteomics and forced expiratory volume in 1 s (FEV(1)), forced vital capacity (FVC) and FEV(1)/FVC ratio. METHODS: We used a discovery and replication approach in two community-based cohorts, EpiHealth and the Malmö Offspring Study (total n=2874), to cross-sectionally study 242 cardiovascular disease- and metabolism-linked proteins in relation to FEV(1), FVC (both % predicted) and FEV(1)/FVC ratio. A false discovery rate of 5% was used as the significance threshold in the discovery cohort. RESULTS: Plasma fatty acid-binding protein 4, interleukin-1 receptor antagonist, interleukin-6 and leptin were negatively associated with FEV(1) and paraoxonase 3 was positively associated therewith. Fatty acid-binding protein 4, fibroblast growth factor 21, interleukin-1 receptor antagonist, interleukin-6 and leptin were negatively associated with FVC and agouti-related protein, insulin-like growth factor-binding protein 2, paraoxonase 3 and receptor for advanced glycation end products were positively associated therewith. No proteins were associated with FEV(1)/FVC ratio. A sensitivity analysis in EpiHealth revealed only minor changes after excluding individuals with known cardiovascular disease, diabetes or obesity. CONCLUSIONS: Five proteins were associated with both FEV(1) and FVC. Four proteins associated with only FVC and none with FEV(1)/FVC ratio, suggesting associations mainly through lung volume, not airway obstruction. However, additional studies are needed to investigate underlying mechanisms for these findings. |
format | Online Article Text |
id | pubmed-10052712 |
institution | National Center for Biotechnology Information |
language | English |
publishDate | 2023 |
publisher | European Respiratory Society |
record_format | MEDLINE/PubMed |
spelling | pubmed-100527122023-03-30 Cardiovascular disease-linked plasma proteins are mainly associated with lung volume Rydell, Andreas Nerpin, Elisabet Zhou, XingWu Lind, Lars Lindberg, Eva Theorell Haglöw, Jenny Fall, Tove Janson, Christer Lisspers, Karin Elmståhl, Sölve Zaigham, Suneela Melander, Olle Nilsson, Peter M. Ärnlöv, Johan Malinovschi, Andrei ERJ Open Res Original Research Articles BACKGROUND: Epidemiological studies have shown that impaired lung function is common and associated with increased risk of cardiovascular disease. Increased levels of several inflammatory and cardiovascular disease-related plasma proteins have been associated with impaired lung function. The aim was to study the association between plasma proteomics and forced expiratory volume in 1 s (FEV(1)), forced vital capacity (FVC) and FEV(1)/FVC ratio. METHODS: We used a discovery and replication approach in two community-based cohorts, EpiHealth and the Malmö Offspring Study (total n=2874), to cross-sectionally study 242 cardiovascular disease- and metabolism-linked proteins in relation to FEV(1), FVC (both % predicted) and FEV(1)/FVC ratio. A false discovery rate of 5% was used as the significance threshold in the discovery cohort. RESULTS: Plasma fatty acid-binding protein 4, interleukin-1 receptor antagonist, interleukin-6 and leptin were negatively associated with FEV(1) and paraoxonase 3 was positively associated therewith. Fatty acid-binding protein 4, fibroblast growth factor 21, interleukin-1 receptor antagonist, interleukin-6 and leptin were negatively associated with FVC and agouti-related protein, insulin-like growth factor-binding protein 2, paraoxonase 3 and receptor for advanced glycation end products were positively associated therewith. No proteins were associated with FEV(1)/FVC ratio. A sensitivity analysis in EpiHealth revealed only minor changes after excluding individuals with known cardiovascular disease, diabetes or obesity. CONCLUSIONS: Five proteins were associated with both FEV(1) and FVC. Four proteins associated with only FVC and none with FEV(1)/FVC ratio, suggesting associations mainly through lung volume, not airway obstruction. However, additional studies are needed to investigate underlying mechanisms for these findings. European Respiratory Society 2023-03-27 /pmc/articles/PMC10052712/ /pubmed/37009020 http://dx.doi.org/10.1183/23120541.00321-2022 Text en Copyright ©The authors 2023 https://creativecommons.org/licenses/by-nc/4.0/This version is distributed under the terms of the Creative Commons Attribution Non-Commercial Licence 4.0. For commercial reproduction rights and permissions contact permissions@ersnet.org (mailto:permissions@ersnet.org) |
spellingShingle | Original Research Articles Rydell, Andreas Nerpin, Elisabet Zhou, XingWu Lind, Lars Lindberg, Eva Theorell Haglöw, Jenny Fall, Tove Janson, Christer Lisspers, Karin Elmståhl, Sölve Zaigham, Suneela Melander, Olle Nilsson, Peter M. Ärnlöv, Johan Malinovschi, Andrei Cardiovascular disease-linked plasma proteins are mainly associated with lung volume |
title | Cardiovascular disease-linked plasma proteins are mainly associated with lung volume |
title_full | Cardiovascular disease-linked plasma proteins are mainly associated with lung volume |
title_fullStr | Cardiovascular disease-linked plasma proteins are mainly associated with lung volume |
title_full_unstemmed | Cardiovascular disease-linked plasma proteins are mainly associated with lung volume |
title_short | Cardiovascular disease-linked plasma proteins are mainly associated with lung volume |
title_sort | cardiovascular disease-linked plasma proteins are mainly associated with lung volume |
topic | Original Research Articles |
url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10052712/ https://www.ncbi.nlm.nih.gov/pubmed/37009020 http://dx.doi.org/10.1183/23120541.00321-2022 |
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