Cargando…
The Effects of Omega-3 Polyunsaturated Fatty Acids on Breast Cancer as a Preventive Measure or as an Adjunct to Conventional Treatments
In order to understand how omega-3 polyunsaturated fatty acid (ω-3 PUFA) supplements affect breast cancer prevention and treatment, a systematic review of articles published in the last 5 years in two databases was performed. Of the 679 articles identified, only 27 were included and examined based o...
Autores principales: | , , , , , , , , , , |
---|---|
Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
MDPI
2023
|
Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10052714/ https://www.ncbi.nlm.nih.gov/pubmed/36986040 http://dx.doi.org/10.3390/nu15061310 |
_version_ | 1785015225080086528 |
---|---|
author | Theinel, Matheus H. Nucci, Mariana P. Alves, Arielly H. Dias, Olivia F. M. Mamani, Javier B. Garrigós, Murilo M. Oliveira, Fernando A. Rego, Gabriel N. A. Valle, Nicole M. E. Cianciarullo, Gabriela Gamarra, Lionel F. |
author_facet | Theinel, Matheus H. Nucci, Mariana P. Alves, Arielly H. Dias, Olivia F. M. Mamani, Javier B. Garrigós, Murilo M. Oliveira, Fernando A. Rego, Gabriel N. A. Valle, Nicole M. E. Cianciarullo, Gabriela Gamarra, Lionel F. |
author_sort | Theinel, Matheus H. |
collection | PubMed |
description | In order to understand how omega-3 polyunsaturated fatty acid (ω-3 PUFA) supplements affect breast cancer prevention and treatment, a systematic review of articles published in the last 5 years in two databases was performed. Of the 679 articles identified, only 27 were included and examined based on five topics, taking into account: the induction type of the breast cancer used in animal models; the characteristics of the induction model by cell transplantation; the experimental design of the ω-3 supplementation—combined or not with a treatment antitumor drug; the fatty acids (FAs) composition used; the analysis of the studies’ outcomes. There are diverse and well-established animal models of breast cancer in the literature, with very relevant histological and molecular similarities depending on the specific objective of the study, such as whether the method of tumor induction was transgenic, by cell transplantation, or by oncogenic drugs. The analyses of outcomes were mainly focused on monitoring tumor growth, body/tumor weight, and molecular, genetic, or histological analyses, and few studies evaluated latency, survival, or metastases. The best results occurred when supplementation with ω-3 PUFA was associated with antitumor drugs, especially in the analysis of metastases and volume/weight of tumors or when the supplementation was started early and maintained for a long time. However, the beneficial effect of ω-3 PUFA supplementation when not associated with an antitumor agent remains unclear. |
format | Online Article Text |
id | pubmed-10052714 |
institution | National Center for Biotechnology Information |
language | English |
publishDate | 2023 |
publisher | MDPI |
record_format | MEDLINE/PubMed |
spelling | pubmed-100527142023-03-30 The Effects of Omega-3 Polyunsaturated Fatty Acids on Breast Cancer as a Preventive Measure or as an Adjunct to Conventional Treatments Theinel, Matheus H. Nucci, Mariana P. Alves, Arielly H. Dias, Olivia F. M. Mamani, Javier B. Garrigós, Murilo M. Oliveira, Fernando A. Rego, Gabriel N. A. Valle, Nicole M. E. Cianciarullo, Gabriela Gamarra, Lionel F. Nutrients Review In order to understand how omega-3 polyunsaturated fatty acid (ω-3 PUFA) supplements affect breast cancer prevention and treatment, a systematic review of articles published in the last 5 years in two databases was performed. Of the 679 articles identified, only 27 were included and examined based on five topics, taking into account: the induction type of the breast cancer used in animal models; the characteristics of the induction model by cell transplantation; the experimental design of the ω-3 supplementation—combined or not with a treatment antitumor drug; the fatty acids (FAs) composition used; the analysis of the studies’ outcomes. There are diverse and well-established animal models of breast cancer in the literature, with very relevant histological and molecular similarities depending on the specific objective of the study, such as whether the method of tumor induction was transgenic, by cell transplantation, or by oncogenic drugs. The analyses of outcomes were mainly focused on monitoring tumor growth, body/tumor weight, and molecular, genetic, or histological analyses, and few studies evaluated latency, survival, or metastases. The best results occurred when supplementation with ω-3 PUFA was associated with antitumor drugs, especially in the analysis of metastases and volume/weight of tumors or when the supplementation was started early and maintained for a long time. However, the beneficial effect of ω-3 PUFA supplementation when not associated with an antitumor agent remains unclear. MDPI 2023-03-07 /pmc/articles/PMC10052714/ /pubmed/36986040 http://dx.doi.org/10.3390/nu15061310 Text en © 2023 by the authors. https://creativecommons.org/licenses/by/4.0/Licensee MDPI, Basel, Switzerland. This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution (CC BY) license (https://creativecommons.org/licenses/by/4.0/). |
spellingShingle | Review Theinel, Matheus H. Nucci, Mariana P. Alves, Arielly H. Dias, Olivia F. M. Mamani, Javier B. Garrigós, Murilo M. Oliveira, Fernando A. Rego, Gabriel N. A. Valle, Nicole M. E. Cianciarullo, Gabriela Gamarra, Lionel F. The Effects of Omega-3 Polyunsaturated Fatty Acids on Breast Cancer as a Preventive Measure or as an Adjunct to Conventional Treatments |
title | The Effects of Omega-3 Polyunsaturated Fatty Acids on Breast Cancer as a Preventive Measure or as an Adjunct to Conventional Treatments |
title_full | The Effects of Omega-3 Polyunsaturated Fatty Acids on Breast Cancer as a Preventive Measure or as an Adjunct to Conventional Treatments |
title_fullStr | The Effects of Omega-3 Polyunsaturated Fatty Acids on Breast Cancer as a Preventive Measure or as an Adjunct to Conventional Treatments |
title_full_unstemmed | The Effects of Omega-3 Polyunsaturated Fatty Acids on Breast Cancer as a Preventive Measure or as an Adjunct to Conventional Treatments |
title_short | The Effects of Omega-3 Polyunsaturated Fatty Acids on Breast Cancer as a Preventive Measure or as an Adjunct to Conventional Treatments |
title_sort | effects of omega-3 polyunsaturated fatty acids on breast cancer as a preventive measure or as an adjunct to conventional treatments |
topic | Review |
url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10052714/ https://www.ncbi.nlm.nih.gov/pubmed/36986040 http://dx.doi.org/10.3390/nu15061310 |
work_keys_str_mv | AT theinelmatheush theeffectsofomega3polyunsaturatedfattyacidsonbreastcancerasapreventivemeasureorasanadjuncttoconventionaltreatments AT nuccimarianap theeffectsofomega3polyunsaturatedfattyacidsonbreastcancerasapreventivemeasureorasanadjuncttoconventionaltreatments AT alvesariellyh theeffectsofomega3polyunsaturatedfattyacidsonbreastcancerasapreventivemeasureorasanadjuncttoconventionaltreatments AT diasoliviafm theeffectsofomega3polyunsaturatedfattyacidsonbreastcancerasapreventivemeasureorasanadjuncttoconventionaltreatments AT mamanijavierb theeffectsofomega3polyunsaturatedfattyacidsonbreastcancerasapreventivemeasureorasanadjuncttoconventionaltreatments AT garrigosmurilom theeffectsofomega3polyunsaturatedfattyacidsonbreastcancerasapreventivemeasureorasanadjuncttoconventionaltreatments AT oliveirafernandoa theeffectsofomega3polyunsaturatedfattyacidsonbreastcancerasapreventivemeasureorasanadjuncttoconventionaltreatments AT regogabrielna theeffectsofomega3polyunsaturatedfattyacidsonbreastcancerasapreventivemeasureorasanadjuncttoconventionaltreatments AT vallenicoleme theeffectsofomega3polyunsaturatedfattyacidsonbreastcancerasapreventivemeasureorasanadjuncttoconventionaltreatments AT cianciarullogabriela theeffectsofomega3polyunsaturatedfattyacidsonbreastcancerasapreventivemeasureorasanadjuncttoconventionaltreatments AT gamarralionelf theeffectsofomega3polyunsaturatedfattyacidsonbreastcancerasapreventivemeasureorasanadjuncttoconventionaltreatments AT theinelmatheush effectsofomega3polyunsaturatedfattyacidsonbreastcancerasapreventivemeasureorasanadjuncttoconventionaltreatments AT nuccimarianap effectsofomega3polyunsaturatedfattyacidsonbreastcancerasapreventivemeasureorasanadjuncttoconventionaltreatments AT alvesariellyh effectsofomega3polyunsaturatedfattyacidsonbreastcancerasapreventivemeasureorasanadjuncttoconventionaltreatments AT diasoliviafm effectsofomega3polyunsaturatedfattyacidsonbreastcancerasapreventivemeasureorasanadjuncttoconventionaltreatments AT mamanijavierb effectsofomega3polyunsaturatedfattyacidsonbreastcancerasapreventivemeasureorasanadjuncttoconventionaltreatments AT garrigosmurilom effectsofomega3polyunsaturatedfattyacidsonbreastcancerasapreventivemeasureorasanadjuncttoconventionaltreatments AT oliveirafernandoa effectsofomega3polyunsaturatedfattyacidsonbreastcancerasapreventivemeasureorasanadjuncttoconventionaltreatments AT regogabrielna effectsofomega3polyunsaturatedfattyacidsonbreastcancerasapreventivemeasureorasanadjuncttoconventionaltreatments AT vallenicoleme effectsofomega3polyunsaturatedfattyacidsonbreastcancerasapreventivemeasureorasanadjuncttoconventionaltreatments AT cianciarullogabriela effectsofomega3polyunsaturatedfattyacidsonbreastcancerasapreventivemeasureorasanadjuncttoconventionaltreatments AT gamarralionelf effectsofomega3polyunsaturatedfattyacidsonbreastcancerasapreventivemeasureorasanadjuncttoconventionaltreatments |