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Self-Assembled Lecithin-Chitosan Nanoparticles Improved Rotigotine Nose-to-Brain Delivery and Brain Targeting Efficiency

Rotigotine (RTG) is a non-ergoline dopamine agonist and an approved drug for treating Parkinson’s disease. However, its clinical use is limited due to various problems, viz. poor oral bioavailability (<1%), low aqueous solubility, and extensive first-pass metabolism. In this study, rotigotine-loa...

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Detalles Bibliográficos
Autores principales:	Saha, Paramita, Singh, Prabhjeet, Kathuria, Himanshu, Chitkara, Deepak, Pandey, Murali Monohar
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	MDPI 2023
Materias:	Article
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10052746/ https://www.ncbi.nlm.nih.gov/pubmed/36986712 http://dx.doi.org/10.3390/pharmaceutics15030851

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