Cargando…

Microneedles in Advanced Microfluidic Systems: A Systematic Review throughout Lab and Organ-on-a-Chip Applications

Microneedles (MNs) have been widely used in biomedical applications for drug delivery and biomarker detection purposes. Furthermore, MNs can also be used as a stand-alone tool to be combined with microfluidic devices. For that purpose, lab- or organ-on-a-chip are being developed. This systematic rev...

Descripción completa

Detalles Bibliográficos
Autores principales: Maia, Renata, Carvalho, Violeta, Lima, Rui, Minas, Graça, Rodrigues, Raquel O.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: MDPI 2023
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10052751/
https://www.ncbi.nlm.nih.gov/pubmed/36986653
http://dx.doi.org/10.3390/pharmaceutics15030792
_version_ 1785015233715109888
author Maia, Renata
Carvalho, Violeta
Lima, Rui
Minas, Graça
Rodrigues, Raquel O.
author_facet Maia, Renata
Carvalho, Violeta
Lima, Rui
Minas, Graça
Rodrigues, Raquel O.
author_sort Maia, Renata
collection PubMed
description Microneedles (MNs) have been widely used in biomedical applications for drug delivery and biomarker detection purposes. Furthermore, MNs can also be used as a stand-alone tool to be combined with microfluidic devices. For that purpose, lab- or organ-on-a-chip are being developed. This systematic review aims to summarize the most recent progress in these emerging systems, to identify their advantages and limitations, and discuss promising potential applications of MNs in microfluidics. Therefore, three databases were used to search papers of interest, and their selection was made following the guidelines for systematic reviews proposed by PRISMA. In the selected studies, the MNs type, fabrication strategy, materials, and function/application were evaluated. The literature reviewed showed that although the use of MNs for lab-on-a-chip has been more explored than for organ-on-a-chip, some recent studies have explored this applicability with great potential for the monitoring of organ models. Overall, it is shown that the presence of MNs in advanced microfluidic devices can simplify drug delivery and microinjection, as well as fluid extraction for biomarker detection by using integrated biosensors, which is a promising tool to precisely monitor, in real-time, different kinds of biomarkers in lab- and organ-on-a-chip platforms.
format Online
Article
Text
id pubmed-10052751
institution National Center for Biotechnology Information
language English
publishDate 2023
publisher MDPI
record_format MEDLINE/PubMed
spelling pubmed-100527512023-03-30 Microneedles in Advanced Microfluidic Systems: A Systematic Review throughout Lab and Organ-on-a-Chip Applications Maia, Renata Carvalho, Violeta Lima, Rui Minas, Graça Rodrigues, Raquel O. Pharmaceutics Systematic Review Microneedles (MNs) have been widely used in biomedical applications for drug delivery and biomarker detection purposes. Furthermore, MNs can also be used as a stand-alone tool to be combined with microfluidic devices. For that purpose, lab- or organ-on-a-chip are being developed. This systematic review aims to summarize the most recent progress in these emerging systems, to identify their advantages and limitations, and discuss promising potential applications of MNs in microfluidics. Therefore, three databases were used to search papers of interest, and their selection was made following the guidelines for systematic reviews proposed by PRISMA. In the selected studies, the MNs type, fabrication strategy, materials, and function/application were evaluated. The literature reviewed showed that although the use of MNs for lab-on-a-chip has been more explored than for organ-on-a-chip, some recent studies have explored this applicability with great potential for the monitoring of organ models. Overall, it is shown that the presence of MNs in advanced microfluidic devices can simplify drug delivery and microinjection, as well as fluid extraction for biomarker detection by using integrated biosensors, which is a promising tool to precisely monitor, in real-time, different kinds of biomarkers in lab- and organ-on-a-chip platforms. MDPI 2023-02-28 /pmc/articles/PMC10052751/ /pubmed/36986653 http://dx.doi.org/10.3390/pharmaceutics15030792 Text en © 2023 by the authors. https://creativecommons.org/licenses/by/4.0/Licensee MDPI, Basel, Switzerland. This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution (CC BY) license (https://creativecommons.org/licenses/by/4.0/).
spellingShingle Systematic Review
Maia, Renata
Carvalho, Violeta
Lima, Rui
Minas, Graça
Rodrigues, Raquel O.
Microneedles in Advanced Microfluidic Systems: A Systematic Review throughout Lab and Organ-on-a-Chip Applications
title Microneedles in Advanced Microfluidic Systems: A Systematic Review throughout Lab and Organ-on-a-Chip Applications
title_full Microneedles in Advanced Microfluidic Systems: A Systematic Review throughout Lab and Organ-on-a-Chip Applications
title_fullStr Microneedles in Advanced Microfluidic Systems: A Systematic Review throughout Lab and Organ-on-a-Chip Applications
title_full_unstemmed Microneedles in Advanced Microfluidic Systems: A Systematic Review throughout Lab and Organ-on-a-Chip Applications
title_short Microneedles in Advanced Microfluidic Systems: A Systematic Review throughout Lab and Organ-on-a-Chip Applications
title_sort microneedles in advanced microfluidic systems: a systematic review throughout lab and organ-on-a-chip applications
topic Systematic Review
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10052751/
https://www.ncbi.nlm.nih.gov/pubmed/36986653
http://dx.doi.org/10.3390/pharmaceutics15030792
work_keys_str_mv AT maiarenata microneedlesinadvancedmicrofluidicsystemsasystematicreviewthroughoutlabandorganonachipapplications
AT carvalhovioleta microneedlesinadvancedmicrofluidicsystemsasystematicreviewthroughoutlabandorganonachipapplications
AT limarui microneedlesinadvancedmicrofluidicsystemsasystematicreviewthroughoutlabandorganonachipapplications
AT minasgraca microneedlesinadvancedmicrofluidicsystemsasystematicreviewthroughoutlabandorganonachipapplications
AT rodriguesraquelo microneedlesinadvancedmicrofluidicsystemsasystematicreviewthroughoutlabandorganonachipapplications