Discovery and characterization of the covalent SARS-CoV-2 3CL(pro) inhibitors from Ginkgo biloba extract via integrating chemoproteomic and biochemical approaches

BACKGROUND: The 3C-like proteases (3CL(pro)s) are cysteine-rich homodimeric proteins and can be covalently modified by numerous natural and synthetic compounds, which in turn, block the proteolytic activity or the formation of enzymatically active dimeric forms. Although herbal medicines have been w...

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Detalles Bibliográficos
Autores principales: Zhang, Ya-Ni, Zhu, Guang-Hao, Liu, Wei, Xiong, Yuan, Hu, Qing, Zhuang, Xiao-Yu, Jia, Gui-Hua, Zhang, Wei-Dong, Ge, Guang-Bo
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Elsevier GmbH. 2023
Materias:
Original Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10052880/
https://www.ncbi.nlm.nih.gov/pubmed/37037086
http://dx.doi.org/10.1016/j.phymed.2023.154796

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10052880/
https://www.ncbi.nlm.nih.gov/pubmed/37037086
http://dx.doi.org/10.1016/j.phymed.2023.154796

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