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The Impact of Endometrioma on Embryo Quality in In Vitro Fertilization: A Retrospective Cohort Study

The influence of endometrioma on oocyte and embryo competence is inconclusive. Furthermore, the benefits of surgical treatment remain uncertain. This study aimed to investigate the effect of endometrioma on oocyte and embryo quality from a morphological perspective and further explore whether surger...

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Autores principales: Dongye, Houjin, Tian, Yizheng, Qi, Dan, Du, Yanbo, Yan, Lei
Formato: Online Artículo Texto
Lenguaje:English
Publicado: MDPI 2023
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10052961/
https://www.ncbi.nlm.nih.gov/pubmed/36983416
http://dx.doi.org/10.3390/jcm12062416
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author Dongye, Houjin
Tian, Yizheng
Qi, Dan
Du, Yanbo
Yan, Lei
author_facet Dongye, Houjin
Tian, Yizheng
Qi, Dan
Du, Yanbo
Yan, Lei
author_sort Dongye, Houjin
collection PubMed
description The influence of endometrioma on oocyte and embryo competence is inconclusive. Furthermore, the benefits of surgical treatment remain uncertain. This study aimed to investigate the effect of endometrioma on oocyte and embryo quality from a morphological perspective and further explore whether surgery could contribute to improving oocyte and embryo competence. A total of 664 IVF cycles with endometrioma (538 cycles underwent surgeries) and 3133 IVF cycles from the control group were included. The propensity score matching was used to balance the baseline differences between groups. There was a lower MII oocyte rate (85.0% versus 87.8%, p < 0.001; 84.9% versus 87.6%, p = 0.001) and a similar good-quality embryos rate in women with endometrioma (and those who underwent surgeries) compared with control group. For women with endometrioma, the rates of blastocyst development (67.1% versus 60.2%; p = 0.013) and good blastocyst development (40.7% versus 35.2%; p = 0.049) were significantly higher in those who had undergone surgical treatment compared with those who had not, but the rates of MII oocytes (79.9% versus 87.7%; p < 0.001) and normal fertilization (55.2% versus 66.2%; p < 0.001) were lower. The study indicates that endometrioma, including its surgical treatment, compromises the oocyte maturity not the embryo quality at the cleavage stage; however, the surgery seems to contribute to improving blastocyst development.
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spelling pubmed-100529612023-03-30 The Impact of Endometrioma on Embryo Quality in In Vitro Fertilization: A Retrospective Cohort Study Dongye, Houjin Tian, Yizheng Qi, Dan Du, Yanbo Yan, Lei J Clin Med Article The influence of endometrioma on oocyte and embryo competence is inconclusive. Furthermore, the benefits of surgical treatment remain uncertain. This study aimed to investigate the effect of endometrioma on oocyte and embryo quality from a morphological perspective and further explore whether surgery could contribute to improving oocyte and embryo competence. A total of 664 IVF cycles with endometrioma (538 cycles underwent surgeries) and 3133 IVF cycles from the control group were included. The propensity score matching was used to balance the baseline differences between groups. There was a lower MII oocyte rate (85.0% versus 87.8%, p < 0.001; 84.9% versus 87.6%, p = 0.001) and a similar good-quality embryos rate in women with endometrioma (and those who underwent surgeries) compared with control group. For women with endometrioma, the rates of blastocyst development (67.1% versus 60.2%; p = 0.013) and good blastocyst development (40.7% versus 35.2%; p = 0.049) were significantly higher in those who had undergone surgical treatment compared with those who had not, but the rates of MII oocytes (79.9% versus 87.7%; p < 0.001) and normal fertilization (55.2% versus 66.2%; p < 0.001) were lower. The study indicates that endometrioma, including its surgical treatment, compromises the oocyte maturity not the embryo quality at the cleavage stage; however, the surgery seems to contribute to improving blastocyst development. MDPI 2023-03-21 /pmc/articles/PMC10052961/ /pubmed/36983416 http://dx.doi.org/10.3390/jcm12062416 Text en © 2023 by the authors. https://creativecommons.org/licenses/by/4.0/Licensee MDPI, Basel, Switzerland. This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution (CC BY) license (https://creativecommons.org/licenses/by/4.0/).
spellingShingle Article
Dongye, Houjin
Tian, Yizheng
Qi, Dan
Du, Yanbo
Yan, Lei
The Impact of Endometrioma on Embryo Quality in In Vitro Fertilization: A Retrospective Cohort Study
title The Impact of Endometrioma on Embryo Quality in In Vitro Fertilization: A Retrospective Cohort Study
title_full The Impact of Endometrioma on Embryo Quality in In Vitro Fertilization: A Retrospective Cohort Study
title_fullStr The Impact of Endometrioma on Embryo Quality in In Vitro Fertilization: A Retrospective Cohort Study
title_full_unstemmed The Impact of Endometrioma on Embryo Quality in In Vitro Fertilization: A Retrospective Cohort Study
title_short The Impact of Endometrioma on Embryo Quality in In Vitro Fertilization: A Retrospective Cohort Study
title_sort impact of endometrioma on embryo quality in in vitro fertilization: a retrospective cohort study
topic Article
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10052961/
https://www.ncbi.nlm.nih.gov/pubmed/36983416
http://dx.doi.org/10.3390/jcm12062416
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