Study on Pharmacokinetics and Metabolic Profiles of Novel Potential PLK-1 Inhibitors by UHPLC-MS/MS Combined with UHPLC-Q-Orbitrap/HRMS

PLK-1 (Polo-like kinase-1) plays an essential role in cytokinesis, and its aberrant expression is considered to be keenly associated with a wide range of cancers. It has been selected as an appealing target and small-molecule inhibitors have been developed and studied in clinical trials. Unfortunate...

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Detalles Bibliográficos
Autores principales: Wang, Lin, Lei, Hui, Lu, Jing, Wang, Wenyan, Liu, Chunjiao, Wang, Yunjie, Yang, Yifei, Tian, Jingwei, Zhang, Jianzhao
Formato: Online Artículo Texto
Lenguaje:English
Publicado: MDPI 2023
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10053003/
https://www.ncbi.nlm.nih.gov/pubmed/36985522
http://dx.doi.org/10.3390/molecules28062550

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10053003/
https://www.ncbi.nlm.nih.gov/pubmed/36985522
http://dx.doi.org/10.3390/molecules28062550

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