Cargando…

Study on Pharmacokinetics and Metabolic Profiles of Novel Potential PLK-1 Inhibitors by UHPLC-MS/MS Combined with UHPLC-Q-Orbitrap/HRMS

PLK-1 (Polo-like kinase-1) plays an essential role in cytokinesis, and its aberrant expression is considered to be keenly associated with a wide range of cancers. It has been selected as an appealing target and small-molecule inhibitors have been developed and studied in clinical trials. Unfortunate...

Descripción completa

Detalles Bibliográficos
Autores principales:	Wang, Lin, Lei, Hui, Lu, Jing, Wang, Wenyan, Liu, Chunjiao, Wang, Yunjie, Yang, Yifei, Tian, Jingwei, Zhang, Jianzhao
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	MDPI 2023
Materias:	Article
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10053003/ https://www.ncbi.nlm.nih.gov/pubmed/36985522 http://dx.doi.org/10.3390/molecules28062550

Ejemplares similares

Pharmacokinetics and Metabolism Research of Shenkang Injection in Rats Based on UHPLC-MS/MS and UHPLC-Q-Orbitrap HRMS
por: Jiang, Xiaofang, et al.
Publicado: (2020)

Dynamic profiling of intact glucosinolates in radish by combining UHPLC-HRMS/MS and UHPLC-QqQ-MS/MS
por: Yan, Chenghuan, et al.
Publicado: (2023)

Characterization of URB Series Synthetic Cannabinoids by HRMS and UHPLC–MS/MS
por: Agostini, Marco, et al.
Publicado: (2023)

Chemical profiling analysis of Maca using UHPLC-ESI-Orbitrap MS coupled with UHPLC-ESI-QqQ MS and the neuroprotective study on its active ingredients
por: Zhou, Yanyan, et al.
Publicado: (2017)

Analysis of isoquinoline alkaloids from Mahonia leschenaultia and Mahonia napaulensis roots using UHPLC-Orbitrap-MS(n) and UHPLC-QqQ(LIT)-MS/MS
por: Singh, Awantika, et al.
Publicado: (2017)

Pharmacokinetics and Metabolism Study of Deep-Sea-Derived Butyrolactone I in Rats by UHPLC–MS/MS and UHPLC–Q-TOF-MS
por: Wu, Liang, et al.
Publicado: (2021)

Qualitative Profiling and Quantitative Analysis of Major Constituents in Jinmu-tang by UHPLC-Q-Orbitrap-MS and UPLC-TQ-MS/MS
por: Jang, Seol, et al.
Publicado: (2022)

Identification of the metabolites of isochlorogenic acid A in rats by UHPLC-Q-Exactive Orbitrap MS
por: Gong, Kaiyan, et al.
Publicado: (2020)

Antiseptic Activity of Ethnomedicinal Xuebijing Revealed by the Metabolomics Analysis Using UHPLC-Q-Orbitrap HRMS
por: Zuo, Lihua, et al.
Publicado: (2018)

Analysis of Isoflavones in Pueraria by UHPLC-Q-Orbitrap HRMS and Study on α-Glucosidase Inhibitory Activity
por: Yang, Yan, et al.
Publicado: (2022)

Chemical Profile Determination and Quantitative Analysis of Components in Oryeong-san Using UHPLC-Q-Orbitrap-MS and UPLC-TQ-MS/MS
por: Jang, Seol, et al.
Publicado: (2023)

Chemical Comparison of White Ginseng before and after Extrusion by UHPLC-Q-Orbitrap-MS/MS and Multivariate Statistical Analysis
por: Guo, Yun-Long, et al.
Publicado: (2020)

Simultaneously qualitative and quantitative analysis of the representative components in Kadsura heteroclita stem by UHPLC-Q-Orbitrap HRMS
por: Liu, Qian-qian, et al.
Publicado: (2021)

Identification for metabolism profiles and pharmacokinetic studies of tradition Chinese prescription Ji-Ming-San and its major metabolites in rats by UHPLC-Q-TOF-MS/MS and UHPLC-MS/MS
por: Hsieh, Cheng-Yang, et al.
Publicado: (2023)

Phytochemistry and Antioxidant Activities of the Rhizome and Radix of Millettia speciosa Based on UHPLC-Q-Exactive Orbitrap-MS
por: Zhang, Jianguang, et al.
Publicado: (2022)

Uncovering the Dissipation of Chlorantraniliprole in Tomatoes: Identifying Transformation Products (TPs) and Coformulants in Greenhouse and Laboratory Studies by UHPLC-Q-Orbitrap-MS and GC-Q-Orbitrap-MS
por: Maldonado-Reina, Antonio Jesús, et al.
Publicado: (2023)

In Vivo Metabolite Profiling of DMU-212 in Apc(Min/+) Mice Using UHPLC-Q/Orbitrap/LTQ MS
por: Li, Jing, et al.
Publicado: (2023)

In Vivo Antihypertensive Activity and UHPLC-Orbitrap-HRMS Profiling of Cuphea ignea A. DC.
por: Ismail, Walaa M., et al.
Publicado: (2022)

Target Analysis and Retrospective Screening of Multiple Mycotoxins in Pet Food Using UHPLC-Q-Orbitrap HRMS
por: Castaldo, Luigi, et al.
Publicado: (2019)

Identification of Chemical Composition of Leaves and Flowers from Paeonia rockii by UHPLC-Q-Exactive Orbitrap HRMS
por: Li, Jinhua, et al.
Publicado: (2016)

Analysis of Phenolic Compounds in Commercial Cannabis sativa L. Inflorescences Using UHPLC-Q-Orbitrap HRMS
por: Izzo, Luana, et al.
Publicado: (2020)

SWATH-MS screening strategy for the determination of food dyes in spices by UHPLC-HRMS
por: Périat, Aurélie, et al.
Publicado: (2019)

UHPLC-HRMS/MS on untargeted metabolomics: a case study with Copaifera (Fabaceae)
por: Antonio, Ananda da Silva, et al.
Publicado: (2021)

Mycotoxin Occurrence and Risk Assessment in Gluten-Free Pasta through UHPLC-Q-Exactive Orbitrap MS
por: Tolosa, Josefa, et al.
Publicado: (2021)

Phenolic Compounds in Chilean Mistletoe (Quintral, Tristerix tetrandus) Analyzed by UHPLC–Q/Orbitrap/MS/MS and Its Antioxidant Properties
por: Simirgiotis, Mario J., et al.
Publicado: (2016)

Structural Identification of Impurities in Pioglitazone Hydrochloride Preparations by 2D-UHPLC-Q-Exactive Orbitrap HRMS and Their Toxicity Prediction
por: Zhang, Dandan, et al.
Publicado: (2023)

Metabolic profiling and pharmacokinetic studies of Baihu-Guizhi decoction in rats by UFLC-Q-TOF–MS/MS and UHPLC-Q-TRAP-MS/MS
por: He, Yan, et al.
Publicado: (2022)

Identification and Pharmacokinetic Studies on Complanatuside and Its Major Metabolites in Rats by UHPLC-Q-TOF-MS/MS and LC-MS/MS
por: Yao, Yu-Feng, et al.
Publicado: (2018)

Rapid identification of chemical components in Xuelian granule by UHPLC-Q-orbitrap-HRMS based on enzyme activity in vitro
por: Taximaimaiti, Xiatiguli, et al.
Publicado: (2023)

Stereoselective pharmacokinetic study of epiprogoitrin and progoitrin in rats with UHPLC–MS/MS method
por: Xu, Yan, et al.
Publicado: (2020)

Identification of Phenolic Compounds from Hancornia speciosa (Apocynaceae) Leaves by UHPLC Orbitrap-HRMS
por: Bastos, Katherine Xavier, et al.
Publicado: (2017)

Rapid Discovery of the Potential Toxic Compounds in Polygonum multiflorum by UHPLC/Q-Orbitrap-MS-Based Metabolomics and Correlation Analysis
por: Han, Lifeng, et al.
Publicado: (2019)

Screening of Quality Markers During the Processing of Reynoutria multiflora Based on the UHPLC-Q-Exactive Plus Orbitrap MS/MS Metabolomic Method
por: Bai, Junqi, et al.
Publicado: (2021)

UHPLC-Q-Orbitrap-MS-Based Metabolomics Reveals Chemical Variations of Two Types of Rhizomes of Polygonatum sibiricum
por: Luo, Gelian, et al.
Publicado: (2022)

Untargeted Lipidomics and Chemometric Tools for the Characterization and Discrimination of Irradiated Camembert Cheese Analyzed by UHPLC-Q-Orbitrap-MS
por: Tomaiuolo, Michele, et al.
Publicado: (2023)

Integrating Study on Qualitative and Quantitative Characterization of the Major Constituents in Shuanghuanglian Injection with UHPLC/Q-Orbitrap-MS and UPLC-PDA
por: Xue, Gen, et al.
Publicado: (2021)

Systematically Exploring the Chemical Ingredients and Absorbed Constituents of Polygonum capitatum in Hyperuricemia Rat Plasma Using UHPLC-Q-Orbitrap HRMS
por: Guan, Huanyu, et al.
Publicado: (2022)

Colon Bioaccessibility under In Vitro Gastrointestinal Digestion of Different Coffee Brews Chemically Profiled through UHPLC-Q-Orbitrap HRMS
por: Castaldo, Luigi, et al.
Publicado: (2021)

Profiling of chemical constituents of Matricarla chamomilla L. by UHPLC-Q-Orbitrap-HRMS and in vivo evaluation its anti-asthmatic activity
por: Li, Qian, et al.
Publicado: (2023)

UHPLC-Q-Exactive Orbitrap MS/MS-Based Untargeted Metabolomics and Molecular Networking Reveal the Differential Chemical Constituents of the Bulbs and Flowers of Fritillaria thunbergii
por: Li, Xin, et al.
Publicado: (2022)

Cannot write session to /tmp/vufind_sessions/sess_ono0lavuuaujauq6sdlbfvqunr