Structural and Functional Characterization of the Newly Designed Antimicrobial Peptide Crabrolin21

(1) Background: antimicrobial resistance is becoming a dramatic problem for public health, and the design of new antimicrobial agents is an active research area. (2) Methods: based on our previous work, we designed an improved version of the crabrolin peptide and characterized its functional and str...

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Detalles Bibliográficos
Autores principales: Cantini, Francesca, Giannì, Paola, Bobone, Sara, Troiano, Cassandra, van Ingen, Hugo, Massoud, Renato, Perini, Nicoletta, Migliore, Luciana, Savarin, Philippe, Sanders, Charles, Stella, Lorenzo, Sette, Marco
Formato: Online Artículo Texto
Lenguaje:English
Publicado: MDPI 2023
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10053045/
https://www.ncbi.nlm.nih.gov/pubmed/36984752
http://dx.doi.org/10.3390/membranes13030365
Descripción
Sumario:(1) Background: antimicrobial resistance is becoming a dramatic problem for public health, and the design of new antimicrobial agents is an active research area. (2) Methods: based on our previous work, we designed an improved version of the crabrolin peptide and characterized its functional and structural properties with a wide range of techniques. (3) Results: the newly designed peptide, crabrolin21, is much more active than the previous ones and shows specific selectivity towards bacterial cells. (4) Conclusions: crabrolin21 shows interesting properties and deserves further studies.

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