Structural and Functional Characterization of the Newly Designed Antimicrobial Peptide Crabrolin21

(1) Background: antimicrobial resistance is becoming a dramatic problem for public health, and the design of new antimicrobial agents is an active research area. (2) Methods: based on our previous work, we designed an improved version of the crabrolin peptide and characterized its functional and str...

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Autores principales: Cantini, Francesca, Giannì, Paola, Bobone, Sara, Troiano, Cassandra, van Ingen, Hugo, Massoud, Renato, Perini, Nicoletta, Migliore, Luciana, Savarin, Philippe, Sanders, Charles, Stella, Lorenzo, Sette, Marco
Formato: Online Artículo Texto
Lenguaje:English
Publicado: MDPI 2023
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10053045/
https://www.ncbi.nlm.nih.gov/pubmed/36984752
http://dx.doi.org/10.3390/membranes13030365
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author Cantini, Francesca
Giannì, Paola
Bobone, Sara
Troiano, Cassandra
van Ingen, Hugo
Massoud, Renato
Perini, Nicoletta
Migliore, Luciana
Savarin, Philippe
Sanders, Charles
Stella, Lorenzo
Sette, Marco
author_facet Cantini, Francesca
Giannì, Paola
Bobone, Sara
Troiano, Cassandra
van Ingen, Hugo
Massoud, Renato
Perini, Nicoletta
Migliore, Luciana
Savarin, Philippe
Sanders, Charles
Stella, Lorenzo
Sette, Marco
author_sort Cantini, Francesca
collection PubMed
description (1) Background: antimicrobial resistance is becoming a dramatic problem for public health, and the design of new antimicrobial agents is an active research area. (2) Methods: based on our previous work, we designed an improved version of the crabrolin peptide and characterized its functional and structural properties with a wide range of techniques. (3) Results: the newly designed peptide, crabrolin21, is much more active than the previous ones and shows specific selectivity towards bacterial cells. (4) Conclusions: crabrolin21 shows interesting properties and deserves further studies.
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spelling pubmed-100530452023-03-30 Structural and Functional Characterization of the Newly Designed Antimicrobial Peptide Crabrolin21 Cantini, Francesca Giannì, Paola Bobone, Sara Troiano, Cassandra van Ingen, Hugo Massoud, Renato Perini, Nicoletta Migliore, Luciana Savarin, Philippe Sanders, Charles Stella, Lorenzo Sette, Marco Membranes (Basel) Article (1) Background: antimicrobial resistance is becoming a dramatic problem for public health, and the design of new antimicrobial agents is an active research area. (2) Methods: based on our previous work, we designed an improved version of the crabrolin peptide and characterized its functional and structural properties with a wide range of techniques. (3) Results: the newly designed peptide, crabrolin21, is much more active than the previous ones and shows specific selectivity towards bacterial cells. (4) Conclusions: crabrolin21 shows interesting properties and deserves further studies. MDPI 2023-03-22 /pmc/articles/PMC10053045/ /pubmed/36984752 http://dx.doi.org/10.3390/membranes13030365 Text en © 2023 by the authors. https://creativecommons.org/licenses/by/4.0/Licensee MDPI, Basel, Switzerland. This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution (CC BY) license (https://creativecommons.org/licenses/by/4.0/).
spellingShingle Article
Cantini, Francesca
Giannì, Paola
Bobone, Sara
Troiano, Cassandra
van Ingen, Hugo
Massoud, Renato
Perini, Nicoletta
Migliore, Luciana
Savarin, Philippe
Sanders, Charles
Stella, Lorenzo
Sette, Marco
Structural and Functional Characterization of the Newly Designed Antimicrobial Peptide Crabrolin21
title Structural and Functional Characterization of the Newly Designed Antimicrobial Peptide Crabrolin21
title_full Structural and Functional Characterization of the Newly Designed Antimicrobial Peptide Crabrolin21
title_fullStr Structural and Functional Characterization of the Newly Designed Antimicrobial Peptide Crabrolin21
title_full_unstemmed Structural and Functional Characterization of the Newly Designed Antimicrobial Peptide Crabrolin21
title_short Structural and Functional Characterization of the Newly Designed Antimicrobial Peptide Crabrolin21
title_sort structural and functional characterization of the newly designed antimicrobial peptide crabrolin21
topic Article
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10053045/
https://www.ncbi.nlm.nih.gov/pubmed/36984752
http://dx.doi.org/10.3390/membranes13030365
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